Core-shell microspheres delivering FGF-2 and BMP-2 in different release patterns for bone regeneration
文献类型：期刊论文
| 作者 | Wang Shuo; Ju Wei; Shang Peng; Lei Lei; Nie Hemin |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2015 |
| 英文摘要 | Bone regeneration by applying fibroblast growth factor-2 (FGF-2) plus bone morphogenetic protein-2 (BMP-2) is considered advantageous over a single growth factor (GF) treatment because the spontaneous repair of bone defects is essentially regulated by a series of GFs, including FGF-2 and BMP2. However, the temporal interactions between FGF-2 and BMP-2 remain elusive and how to take full advantage of the interactions is a bottleneck in translating this dual-GF strategy into clinical applications. To compare the long-term effects of different temporal patterns of FGF-2 and BMP-2 on bone regeneration, a novel delivery system is needed. Herein, we report a type of PLLA core-PLGA shell double-walled microsphere. Different release patterns of FGF-2 and BMP-2 in the core and shell, respectively, were achieved due to different distributions of these two GFs. In vivo evaluations of different release patterns of dual GFs using a rat bone graft model suggested that a sequential delivery of FGF-2 and BMP-2 helped bridge and remodel the critical-sized bone grafts more efficiently than the other release patterns. More importantly, core-shell microspheres simultaneously and continuously releasing FGF-2 and BMP-2 resulted in the obvious resorption of grafted bone and bone non-union at 4 weeks. Consistently, the in vitro treatment of bovine bone sections by FGF-2 plus BMP-2 led to enhanced osteoclastogenesis compared to single GF treatments. The temporal organization of FGF-2 and BMP-2 by taking advantage of the core-shell microspheres will enable the development of more efficient devices for bone defects than existing delivery systems |
| 收录类别 | SCI |
| 原文出处 | http://pubs.rsc.org/en/Content/ArticleLanding/2015/TB/c4tb01876a#!divAbstract |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7188]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | JOURNAL OF MATERIALS CHEMISTRY B |
| 推荐引用方式 GB/T 7714 | Wang Shuo,Ju Wei,Shang Peng,et al. Core-shell microspheres delivering FGF-2 and BMP-2 in different release patterns for bone regeneration[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015. |
| APA | Wang Shuo,Ju Wei,Shang Peng,Lei Lei,&Nie Hemin.(2015).Core-shell microspheres delivering FGF-2 and BMP-2 in different release patterns for bone regeneration.JOURNAL OF MATERIALS CHEMISTRY B. |
| MLA | Wang Shuo,et al."Core-shell microspheres delivering FGF-2 and BMP-2 in different release patterns for bone regeneration".JOURNAL OF MATERIALS CHEMISTRY B (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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