Epoxyeicosanoids suppress osteoclastogenesis and prevent ovariectomy-induced bone loss
文献类型：期刊论文
| 作者 | Guan Hanfeng; Zhao Libo; Cao Huijuan; Chen, AM (Chen Anmin; Xiao Jun |
| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2015 |
| 英文摘要 | Epoxyeicosatrienoic acids (EETs) are products of arachidonic acid metabolism catalyzed by cytochrome P450 epoxygenases. These small molecules are autocrine and paracrine lipid mediators with important roles in inflammation, cardiovascular function, and angiogenesis. Recent evidence has highlighted EETs as potent promoters of organ regeneration and malignant metastasis. We speculated that EETs might impact osteoclastogenesis and bone loss. Using both in vitro and in vivo studies, we observed that EETs significantly attenuated bone loss and inhibited osteoclast formation and activity, which were associated with a decreased receptor activator of NF-kappa B ligand (RANKL): osteoprotegerin ratio and serum levels of TNF-alpha and IL-1 beta. At the molecular level, EETs abrogated RANKL-induced activation of NF-kappa B, activator protein-1 (AP-1), and MAPKs, including ERK and JNK, but not p38, during osteoclast formation. EETs also prevented the production of reactive oxygen species (ROS) following RANKL stimulation. As a result, EETs suppressed osteoclast-specific gene expression, including tartrate resistant acid phosphatase (TRAP), cathepsin K (CK), matrix metalloproteinase (MMP)-9, and receptor activator of NF-kappa B (RANK). In conclusion, our findings demonstrate that EETs inhibit osteoclastogenesis through modulation of multiple pathways both upstream and downstream of RANKL signaling. The administration or stabilized endogenous levels of EETs could represent a novel therapeutic strategy for osteoclast-related disorders, such as rheumatoid arthritis and postmenopausal osteoporosis |
| 收录类别 | SCI |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pubmed/25466887 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7190]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | FASEB JOURNAL |
| 推荐引用方式 GB/T 7714 | Guan Hanfeng,Zhao Libo,Cao Huijuan,et al. Epoxyeicosanoids suppress osteoclastogenesis and prevent ovariectomy-induced bone loss[J]. FASEB JOURNAL,2015. |
| APA | Guan Hanfeng,Zhao Libo,Cao Huijuan,Chen, AM ,&Xiao Jun.(2015).Epoxyeicosanoids suppress osteoclastogenesis and prevent ovariectomy-induced bone loss.FASEB JOURNAL. |
| MLA | Guan Hanfeng,et al."Epoxyeicosanoids suppress osteoclastogenesis and prevent ovariectomy-induced bone loss".FASEB JOURNAL (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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