Bacterial inhibition potential of 3D rapid-prototyped magnesium-based porous composite scaffolds-an in vitro efficacy study
文献类型：期刊论文
| 作者 | Rui Ma; Yu-xiao Lai; Long Li; Hong-lue Tan; Jia-li Wang; Ye Li; Ting-ting Tang; Ling Qin |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 英文摘要 | Bone infections are common in trauma-induced open fractures with bone defects. Therefore, developing anti-infection scaffolds for repairing bone defects is desirable. This study develoepd novel Mg-based porous composite scaffolds with a basal matrix composed of poly(lactic-co-glycolicacid) (PLGA) and tricalcium phosphate (TCP). A unique low-temperature rapid prototyping technology was used to fabricate the scaffolds, including PLGA/TCP (PT), PLGA/TCP/5% Mg (PT5M), PLGA/ TCP/10% Mg (PT10M), and PLGA/TCP/15% Mg (PT15M). The bacterial adhesion and biofilm formation of Staphylococcus aureus were evaluated. The results indicated that the Mg-based scaffolds significantly inhibited bacterial adhesion and biofilm formation compared to PT, and the PT10M and PT15M exhibited significantly stronger anti-biofilm ability than PT5M. In vitro degratation tests revealed that the degradation of the Mg-based scaffolds caused an increase of pH, Mg2+ concentration and osmolality, and the increased pH may be one of the major contributing factors to the antibacterial function of the Mg-based scaffolds. Additionally, the PT15M exhibited an inhibitory effect on cell adhesion and proliferation of MC3T3-E1 cells. In conclusion, the PLGA/TCP/Mg scaffolds could inhibit bacterial adhesion and biofilm formation, and the PT10M scaffold was considered to be an effective composition with considerable antibacterial ability and good cytocompatibility. |
| 收录类别 | SCI |
| 原文出处 | http://www.nature.com/articles/srep13775 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7197]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | SCIENTIFIC REPORTS |
| 推荐引用方式 GB/T 7714 | Rui Ma,Yu-xiao Lai,Long Li,et al. Bacterial inhibition potential of 3D rapid-prototyped magnesium-based porous composite scaffolds-an in vitro efficacy study[J]. SCIENTIFIC REPORTS,2015. |
| APA | Rui Ma.,Yu-xiao Lai.,Long Li.,Hong-lue Tan.,Jia-li Wang.,...&Ling Qin.(2015).Bacterial inhibition potential of 3D rapid-prototyped magnesium-based porous composite scaffolds-an in vitro efficacy study.SCIENTIFIC REPORTS. |
| MLA | Rui Ma,et al."Bacterial inhibition potential of 3D rapid-prototyped magnesium-based porous composite scaffolds-an in vitro efficacy study".SCIENTIFIC REPORTS (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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