Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8)
文献类型：期刊论文
| 作者 | An Yun Guo; Kwok Sui Leung; Parco Ming Fai Siu; Jiang Hui Qin; Simon Kwoon Ho Chow; Ling Qin; Chi Yu Li; Wing Hoi Cheung |
| 刊名 | EXPERIMENTAL ANIMALS
 |
| 出版日期 | 2015 |
| 英文摘要 | Sarcopenia is an age-related systemic syndrome with progressive deterioration in skeletal muscle functions and loss in mass. Although the senescence-accelerated mouse P8 (SAMP8) was reported valid for muscular ageing research, there was no report on the details such as sarcopenia onset time. Therefore, this study was to investigate the change of muscle mass, structure and functions during the development of sarcopenia. Besides the average life span, muscle mass, structural and functional measurements were also studied. Male SAMP8 animals were examined at month 6, 7, 8, 9, and 10, in which the right gastrocnemius was isolated and tested for ex vivo contractile properties and fatigability while the contralateral one was harvested for muscle fiber cross-sectional area (FCSA) and typing assessments. Results showed that the peak of muscle mass appeared at month 7 and the onset of contractility decline was observed from month 8. Compared with month 8, most of the functional parameters at month 10 decreased significantly. Structurally, muscle fiber type IIA made up the largest proportion of the gastrocnemius, and the fiber size was found to peak at month 8. Based on the altered muscle mass, structural and functional outcomes, it was concluded that the onset of sarcopenia in SAMP8 animals was at month 8. SAMP8 animals at month 8 should be at pre-sarcopenia stage while month 10 at sarcopenia stage. It is confirmed that SAMP8 mouse can be used in sarcopenia research with established time line in this study. |
| 收录类别 | SCI |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637380/ |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7199]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | EXPERIMENTAL ANIMALS |
| 推荐引用方式 GB/T 7714 | An Yun Guo,Kwok Sui Leung,Parco Ming Fai Siu,et al. Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8)[J]. EXPERIMENTAL ANIMALS,2015. |
| APA | An Yun Guo.,Kwok Sui Leung.,Parco Ming Fai Siu.,Jiang Hui Qin.,Simon Kwoon Ho Chow.,...&Wing Hoi Cheung.(2015).Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8).EXPERIMENTAL ANIMALS. |
| MLA | An Yun Guo,et al."Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8)".EXPERIMENTAL ANIMALS (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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