Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years.
文献类型：期刊论文
| 作者 | Xiao, Yaqiong; Brauer, Jens; Lauckner, Mark; Zhai, Hongchang; Jia, Fucang; Margulies, Daniel S.; Friederici, Angela D. |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2016 |
| 英文摘要 | Resting state studies of spontaneous fluctuations in the functional magnetic resonance imaging (fMRI) blood oxygen level dependent signal have shown great potential in mapping the intrinsic functional connectivity of the human brain underlying cognitive functions. The aim of the present study was to explore thedevelopmental changes in functional networks of the developing human brain exemplified with the language network in typically developing preschool children. To this end, resting-sate fMRI data were obtained from native Chinese children at ages of 3 and 5 years, 15 in each age group. Resting-state functional connectivity (RSFC) was analyzed for four regions of interest; these are the left and right anterior superior temporal gyrus (aSTG), left posterior superior temporal gyrus (pSTG), and left inferior frontal gyrus (IFG). The comparison of these RSFC maps between 3- and 5-year-olds revealed that RSFC decreases in the right aSTG and increases in the left hemisphere between aSTG seed and IFG, between pSTG seed and IFG, as well as between IFG seed and posterior superior temporal sulcus. In a subsequent analysis, functional asymmetry of the language network seeding in aSTG, pSTG and IFG was further investigated. The results showed an increase of left lateralization in both RSFC of pSTG and of IFG from ages 3 to 5 years. The IFG showed a leftward lateralized trend in 3-year-olds, while pSTG demonstrated rightward asymmetry in 5-year-olds. These findings suggest clear developmental trajectories of thelanguage network between 3- and 5-year-olds revealed as a function of age, characterized by increasing long-range connections and dynamic hemispheric lateralization with age. Our study provides new insights into the developmental changes of a well-established functional network in young children and also offers a basis for future cross-culture and cross-age studies of the resting-state language network. |
| 收录类别 | SCI |
| 原文出处 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165802 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10387]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | PLOS ONE |
| 推荐引用方式 GB/T 7714 | Xiao, Yaqiong,Brauer, Jens,Lauckner, Mark,et al. Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years.[J]. PLOS ONE,2016. |
| APA | Xiao, Yaqiong.,Brauer, Jens.,Lauckner, Mark.,Zhai, Hongchang.,Jia, Fucang.,...&Friederici, Angela D..(2016).Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years..PLOS ONE. |
| MLA | Xiao, Yaqiong,et al."Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years.".PLOS ONE (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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