Altered regional homogeneity in epileptic patients with infantile spasm: A resting-state fMRI study
文献类型：期刊论文
| 作者 | Tan, Zhen; Li, Yongxin; Zang, Dongdong; Zhang, Heye; Zhao, Cailei; Jiang, Haibo; Chen, Yan; Cao, Dezhi; Chen, Li; Liao, Jianxiang |
| 刊名 | JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY
 |
| 出版日期 | 2016 |
| 英文摘要 | Infantile spasm (IS) syndrome is an age-related epileptic encephalopathy that occurs in children. The purpose of this study was to investigate regional homogeneity (ReHo) changes in IS patients. Resting-statefMRI was performed on 11 patients with IS, along with 35 age- and sex-matched healthy subjects. Group comparisons between the two groups demonstrate that the pattern of regional synchronization synchronization in IS patients is changed. Decreased ReHo values were found in default mode network, bilateral motor-related areas and left occipital gyrus of the patient group. Increased ReHo was found inregions of cingulum, cerebellum, supplementary motor area and brain deep nucleus, such as hippocampus, caudate, thalamus and insula. The significant differences might indicate that epileptic action have some injurious effects on the motor, executive and cognitive related regions. In addition, ReHo values of left precuneus and right superior frontal gyrus were associated with the epilepsy duration in the IS group. The correlation results indicate that the involvement of these regions may be related to the seizure generation. Our results suggest that IS may have an injurious effect on the brain activation. The findings may shed new light on the understanding the neural mechanism of IS epilepsy. |
| 收录类别 | SCI |
| 原文出处 | http://content.iospress.com/articles/journal-of-x-ray-science-and-technology/xst559 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10401]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY |
| 推荐引用方式 GB/T 7714 | Tan, Zhen,Li, Yongxin,Zang, Dongdong,et al. Altered regional homogeneity in epileptic patients with infantile spasm: A resting-state fMRI study[J]. JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY,2016. |
| APA | Tan, Zhen.,Li, Yongxin.,Zang, Dongdong.,Zhang, Heye.,Zhao, Cailei.,...&uan, Guoming.(2016).Altered regional homogeneity in epileptic patients with infantile spasm: A resting-state fMRI study.JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY. |
| MLA | Tan, Zhen,et al."Altered regional homogeneity in epileptic patients with infantile spasm: A resting-state fMRI study".JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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