Image processing methods to elucidate spatial characteristics of retinal microglia after opticnerve transection
文献类型：期刊论文
| 作者 | Zhang, Y.; Peng, B.; Wang, S.; Liang, Y.X.; Yang, J.; So, K.F.; Yuan, T.F. |
| 刊名 | Scientific Reports
 |
| 出版日期 | 2016 |
| 英文摘要 | Microglia are the mononuclear phagocytes with various functions in the central nervous system, and the morphologies of microglia imply the different stages and functions. In optical nerve transection model of the retina, the retrograde degeneration of retinal ganglion cells induces microglial activations to a unique morphology termed rod microglia. A few studies described the rod microglia in the cortex and retina; however, the spatial characteristic of rod microglia is not fully understood. In this study, we built a mathematical model to characterize the spatial trait of rod microglia. In addition, we developed a Matlab-based image processing pipeline that consists of log enhancement, image segmentation, mathematical morphology based cell detection, area calculation and angle analysis. This computer program provides researchers a powerful tool to quickly analyze the spatial trait of rod microglia. |
| 收录类别 | SCI |
| 原文出处 | http://www.nature.com/articles/srep21816 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10441]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Scientific Reports |
| 推荐引用方式 GB/T 7714 | Zhang, Y.,Peng, B.,Wang, S.,et al. Image processing methods to elucidate spatial characteristics of retinal microglia after opticnerve transection[J]. Scientific Reports,2016. |
| APA | Zhang, Y..,Peng, B..,Wang, S..,Liang, Y.X..,Yang, J..,...&Yuan, T.F..(2016).Image processing methods to elucidate spatial characteristics of retinal microglia after opticnerve transection.Scientific Reports. |
| MLA | Zhang, Y.,et al."Image processing methods to elucidate spatial characteristics of retinal microglia after opticnerve transection".Scientific Reports (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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