Improved Anatomical Specificity of Non-invasive Neuro-stimulation by High Frequency (5 MHz) Ultrasound
文献类型：期刊论文
| 作者 | Li, Guo-Feng; Zhao, Hui-Xia; Zhou, Hui; Yan, Fei; Wang, Jing-Yao; Xu, Chang-Xi; Wang, Cong-Zhi; Niu, Li-Li; Meng, Long; Su, Song |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 英文摘要 | Low frequency ultrasound (<1 MHz) has been demonstrated to be a promising approach for non-invasiveneuro-stimulation. However, the focal width is limited to be half centimeter scale. Minimizing the stimulationregion with higher frequency ultrasound will provide a great opportunity to expand its application. This study first time examines the feasibility of using high frequency (5 MHz) ultrasound to achieve neuro-stimulation in brain, and verifies the anatomical specificity of neuro-stimulation in vivo. 1 MHz and 5 MHz ultrasoundstimulation were evaluated in the same group of mice. Electromyography (EMG) collected from tail muscles together with the motion response videos were analyzed for evaluating the stimulation effects. Our results indicate that 5 MHz ultrasound can successfully achieve neuro-stimulation. The equivalent diameter (ED) ofthe stimulation region with 5 MHz ultrasound (0.29 +/- 0.08 mm) is significantly smaller than that with 1MHz (0.83 +/- 0.11 mm). The response latency of 5 MHz ultrasound (45 +/- 31 ms) is also shorter than thatof 1 MHz ultrasound (208 +/- 111 ms). Consequently, high frequency (5 MHz) ultrasound can successfully activate the brain circuits in mice. It provides a smaller stimulation region, which offers improved anatomicalspecificity for neurostimulation in a non-invasive manner. |
| 收录类别 | SCI |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837374/ |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10453]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | SCIENTIFIC REPORTS |
| 推荐引用方式 GB/T 7714 | Li, Guo-Feng,Zhao, Hui-Xia,Zhou, Hui,et al. Improved Anatomical Specificity of Non-invasive Neuro-stimulation by High Frequency (5 MHz) Ultrasound[J]. SCIENTIFIC REPORTS,2016. |
| APA | Li, Guo-Feng.,Zhao, Hui-Xia.,Zhou, Hui.,Yan, Fei.,Wang, Jing-Yao.,...&Zheng, Hai-Rong.(2016).Improved Anatomical Specificity of Non-invasive Neuro-stimulation by High Frequency (5 MHz) Ultrasound.SCIENTIFIC REPORTS. |
| MLA | Li, Guo-Feng,et al."Improved Anatomical Specificity of Non-invasive Neuro-stimulation by High Frequency (5 MHz) Ultrasound".SCIENTIFIC REPORTS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。