Comparison of image sensitivity between conventional tensor-based and fast diffusion kurtosis imaging protocols in a rodent model of acute ischemic stroke
文献类型：期刊论文
| 作者 | Wu, Yin; Kim, Jinsuh; Chan, Suk-Tak; Zhou, Iris Yuwen; Guo, Yingkun; Igarashi, Takahiro; Zheng, Hairong; Guo, Gang; Sun, Phillip Zhe |
| 刊名 | NMR IN BIOMEDICINE
 |
| 出版日期 | 2016 |
| 英文摘要 | Diffusion kurtosis imaging (DKI) can offer a useful complementary tool to routine diffusion MRI for improved stratification of heterogeneous tissue damage in acute ischemic stroke. However, its relatively long imagingtime has hampered its clinical application in the emergency setting. A recently proposed fast DKI approach substantially shortens the imaging time, which may help to overcome the scan time limitation. However, to date, the sensitivity of the fast DKI protocol for the imaging of acute stroke has not been fully described. Inthis study, we performed routine and fast DKI scans in a rodent model of acute stroke, and compared thesensitivity of diffusivity and kurtosis indices (i.e. axial, radial and mean) in depicting acute ischemic lesions.In addition, we analyzed the contrast-to-noise ratio (CNR) between the ipsilateral ischemic and contralateral normal regions using both conventional and fast DKI methods. We found that the mean kurtosis shows arelative change of 47.1 +/- 7.3% between the ischemic and contralateral normal regions, being the most sensitive parameter in revealing acute ischemic injury. The two DKI methods yielded highly correlated diffusivity and kurtosis measures and lesion volumes (R(2)0.90, p<0.01). Importantly, the fast DKI method exhibited significantly higher CNR of mean kurtosis (1.6 +/- 0.2) compared with the routine tensor protocol (1.3 +/- 0.2, p<0.05), with its CNR per unit time (CNR efficiency) approximately doubled when the scan time was taken into account. In conclusion, the fast DKI method provides excellent sensitivity and efficiency toimage acute ischemic tissue damage, which is essential for image-guided and individualized stroketreatment. |
| 收录类别 | SCI |
| 原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/nbm.3506/pdf |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10460]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | NMR IN BIOMEDICINE |
| 推荐引用方式 GB/T 7714 | Wu, Yin,Kim, Jinsuh,Chan, Suk-Tak,et al. Comparison of image sensitivity between conventional tensor-based and fast diffusion kurtosis imaging protocols in a rodent model of acute ischemic stroke[J]. NMR IN BIOMEDICINE,2016. |
| APA | Wu, Yin.,Kim, Jinsuh.,Chan, Suk-Tak.,Zhou, Iris Yuwen.,Guo, Yingkun.,...&Sun, Phillip Zhe.(2016).Comparison of image sensitivity between conventional tensor-based and fast diffusion kurtosis imaging protocols in a rodent model of acute ischemic stroke.NMR IN BIOMEDICINE. |
| MLA | Wu, Yin,et al."Comparison of image sensitivity between conventional tensor-based and fast diffusion kurtosis imaging protocols in a rodent model of acute ischemic stroke".NMR IN BIOMEDICINE (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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