IR-780 Dye as a Sonosensitizer for Sonodynamic Therapy of Breast Tumor
文献类型：期刊论文
| 作者 | Li, Yekuo; Zhou, Qunfang; Deng, Zhiting; Pan, Min; Liu, Xin; Wu, Junru; Yan, Fei; Zheng, Hairong |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 英文摘要 | Sonodynamic therapy (SDT) has become a new modality for cancer therapy through activating certain chemical sensitizers by ultrasound (US). Discovery and development of novel sonosensitizers are attracting extensive attentions. Here, we introduce IR-780 iodide, a lipophilic heptamethine dye with a peak optical absorption of 780 nm wavelength, which can function as SDT agents for breast cancer treatment. The in vitro cellular uptake, cell viability, and the generation levels of reactive oxygen species (ROS) were examined by using 4T1 breast cancer cells incubated with various concentrations of IR-780 followed by US irradiation. Our results showed a dose-and time-dependent cellular uptake of IR-780 iodide in 4T1 cancer cells. Significant lower viabilities and more necrotic/apoptotic cells were found when these cancer cells were treated with IR-780 iodide with US irradiation. Further analyzing the generation of ROS demonstrated significant increase of O-1(2) level and H2O2, but not center dot OH in the SDT-treated cells. The in vivo anti-tumor efficacy of SDT with IR-780 revealed significant tumor growth inhibition of xenografts of 4T1 cancer cells; it was further confirmed by histological analysis and TUNEL staining. Our results strongly suggest that SDT combined with IR-780 may provide a promising strategy for tumor treatment with minimal side effects. |
| 收录类别 | SCI |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865802/ |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10461]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | SCIENTIFIC REPORTS |
| 推荐引用方式 GB/T 7714 | Li, Yekuo,Zhou, Qunfang,Deng, Zhiting,et al. IR-780 Dye as a Sonosensitizer for Sonodynamic Therapy of Breast Tumor[J]. SCIENTIFIC REPORTS,2016. |
| APA | Li, Yekuo.,Zhou, Qunfang.,Deng, Zhiting.,Pan, Min.,Liu, Xin.,...&Zheng, Hairong.(2016).IR-780 Dye as a Sonosensitizer for Sonodynamic Therapy of Breast Tumor.SCIENTIFIC REPORTS. |
| MLA | Li, Yekuo,et al."IR-780 Dye as a Sonosensitizer for Sonodynamic Therapy of Breast Tumor".SCIENTIFIC REPORTS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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