Monitoring Tumor Hypoxia Using F-18-FMISO PET and Pharmacokinetics Modeling after Photodynamic Therapy
文献类型：期刊论文
| 作者 | Xiao Tong; Avinash Srivatsan; Orit Jacobson; Yu Wang; Zhantong Wang; Xiangyu Yang; Gang Niu; Dale O. Kiesewetter; Hairong Zheng; Xiaoyuan Chen |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 英文摘要 | Photodynamic therapy (PDT) is an efficacious treatment for some types of cancers. However, PDTinduced tumor hypoxia as a result of oxygen consumption and vascular damage can reduce the efficacy of this therapy. Measuring and monitoring intrinsic and PDT-induced tumor hypoxia in vivo during PDT is of high interest for prognostic and treatment evaluation. In the present study, static and dynamic 18F-FMISO PET were performed with mice bearing either U87MG or MDA-MB-435 tumor xenografts immediately before and after PDT at different time points. Significant difference in tumor hypoxia in response to PDT over time was found between the U87MG and MDA-MB-435 tumors in both static and dynamic PET. Dynamic PET with pharmacokinetics modeling further monitored the kinetics of 18F-FMISO retention to hypoxic sites after treatment. The Ki and k3 parametric analysis provided information on tumor hypoxia by distinction of the specific tracer retention in hypoxic sites from its non-specific distribution in tumor. Dynamic 18F-FMISO PET with pharmacokinetics modeling, complementary to static PET analysis, provides a potential imaging tool for more detailed and more accurate quantification of tumor hypoxia during PDT. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10470]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | SCIENTIFIC REPORTS |
| 推荐引用方式 GB/T 7714 | Xiao Tong,Avinash Srivatsan,Orit Jacobson,et al. Monitoring Tumor Hypoxia Using F-18-FMISO PET and Pharmacokinetics Modeling after Photodynamic Therapy[J]. SCIENTIFIC REPORTS,2016. |
| APA | Xiao Tong.,Avinash Srivatsan.,Orit Jacobson.,Yu Wang.,Zhantong Wang.,...&Xiaoyuan Chen.(2016).Monitoring Tumor Hypoxia Using F-18-FMISO PET and Pharmacokinetics Modeling after Photodynamic Therapy.SCIENTIFIC REPORTS. |
| MLA | Xiao Tong,et al."Monitoring Tumor Hypoxia Using F-18-FMISO PET and Pharmacokinetics Modeling after Photodynamic Therapy".SCIENTIFIC REPORTS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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