Hyperthermia-triggered drug delivery from iRGD-modified temperaturesensitive liposomes enhances the anti-tumor efficacy using high intensity focused ultrasound.
文献类型：期刊论文
| 作者 | Deng,Zhiting; Xiao, Yang; Pan, Min; Li, Fei; Duan, Wanlu; Meng, Long; Liu, Xin; Yan, Fei; Zheng, Hairong |
| 刊名 | Journal of Controlled Release
 |
| 出版日期 | 2016 |
| 英文摘要 | An important limitation to successful cancer treatment with chemotherapeutics is the inability to achieve therapeutically effective drug concentrations while avoiding healthy tissue damage. In this work, a new tumor-targeting peptide iRGD (CCRGDKGPDC) was used to modify drug-loaded low temperature-sensitive liposomes (iRGD-LTSL-DOX) to explore the anti-tumor effects in combination with high intensity focused ultrasound (HIFU) in vitro and in vivo. iRGD-LTSL-DOX can specifically target to ανβ3-positive cells and locally release the encapsulated doxorubicin (DOX) in a hyperthermia-triggered manner. In vivo results showed that DOX from iRGD-LTSL-DOX was intravascularly released and rapidly penetrated into tumor interstitial space after HIFU-triggered heat treatment, thereby overcoming the limited tumor penetration of anticancer drugs. Significantly stronger anti-tumor efficacy further supported the effective combination of iRGD-LTSL-DOX with HIFU-induced hyperthermia. Our study provided a novel tumor-targeting LTSL-DOX and demonstrated its usefulness in HIFU-induced hyperthermia-triggered drug delivery |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0168365916310926 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10487]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Journal of Controlled Release |
| 推荐引用方式 GB/T 7714 | Deng,Zhiting,Xiao, Yang,Pan, Min,et al. Hyperthermia-triggered drug delivery from iRGD-modified temperaturesensitive liposomes enhances the anti-tumor efficacy using high intensity focused ultrasound.[J]. Journal of Controlled Release,2016. |
| APA | Deng,Zhiting.,Xiao, Yang.,Pan, Min.,Li, Fei.,Duan, Wanlu.,...&Zheng, Hairong.(2016).Hyperthermia-triggered drug delivery from iRGD-modified temperaturesensitive liposomes enhances the anti-tumor efficacy using high intensity focused ultrasound..Journal of Controlled Release. |
| MLA | Deng,Zhiting,et al."Hyperthermia-triggered drug delivery from iRGD-modified temperaturesensitive liposomes enhances the anti-tumor efficacy using high intensity focused ultrasound.".Journal of Controlled Release (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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