epsilon-Caprolactone-Modified Polyethylenimine as Efficient Nanocarriers for siRNA Delivery in Vivo
文献类型：期刊论文
| 作者 | Lisi Xie; Yan Tan; Zhiyong Wang; Hong Liu; Na Zhang; Chao Zou; Xin Liu; Gang Liu; Jian Lu; Hairong Zheng |
| 刊名 | ACS applied materials & interfaces
 |
| 出版日期 | 2016 |
| 英文摘要 | RNA interference (RNAi) therapy is a promising treatment for various diseases. However, its application is still restricted by the lack of efficient and safe delivery systems. A novel siRNA delivery vehicle based on ε-caprolactone-modified polyethylenimine (PEI-CL) is presented here. The PEI-CL macromolecules with different grafting degrees were synthesized via a simple ring-opening reaction. This macromolecule strongly protects the siRNA from degradation in serum and promotes the cellular uptake and endosomal escape detected via chemical exchange saturation transfer magnetic resonance analysis and fluorescence imaging. The in vivo measurement was performed with HCT-116 colon tumor xenograft that stably expressed luciferase. The data showed that the PEI-CL/siRNA nanocomplexes elicited strong RNAi response. More interestingly, enhanced gene transfection efficiency was achieved by simultaneous cotransfection with siRNA and DNA plasmid via this novel nanosystem. Overall, our study suggests the PEI-CL macromolecule with great promise for siRNA delivery. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.acs.org/doi/abs/10.1021/acsami.6b08542 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10492]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | ACS applied materials & interfaces |
| 推荐引用方式 GB/T 7714 | Lisi Xie,Yan Tan,Zhiyong Wang,et al. epsilon-Caprolactone-Modified Polyethylenimine as Efficient Nanocarriers for siRNA Delivery in Vivo[J]. ACS applied materials & interfaces,2016. |
| APA | Lisi Xie.,Yan Tan.,Zhiyong Wang.,Hong Liu.,Na Zhang.,...&Hairong Zheng.(2016).epsilon-Caprolactone-Modified Polyethylenimine as Efficient Nanocarriers for siRNA Delivery in Vivo.ACS applied materials & interfaces. |
| MLA | Lisi Xie,et al."epsilon-Caprolactone-Modified Polyethylenimine as Efficient Nanocarriers for siRNA Delivery in Vivo".ACS applied materials & interfaces (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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