Biodegradable Magnesium (Mg) Implantation Does Not Impose Related Metabolic Disorders in Rats with Chronic Renal Failure
文献类型：期刊论文
| 作者 | Wang, Jiali; Xu, Jiankun; Liu, Waiching; Li, Yangde; Qin, Ling |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 英文摘要 | Mg and its alloys have been considered as one of the most promising biodegradable medical devices, but it was still unclear whether hypermagnesemia involved health risks would occur in persons with kidney disease due to their deteriorated kidney function for Mg ions excretion from their body. In this study, we established a chronic renal failure (CRF) model in rats induced by adenine administration prior to Mg implantation, aiming to predict if CRF patients are suitable for the use of Mg implants. The results showed that Mg levels in serum, urine, feces and internal organs had no significant changes after Mg implantation for both normal and CRF rats. Biochemical indices detection and histopathological analysis in kidney, liver and heart tissue confirmed that Mg implants did not induce any extra damage in animals even with renal failure. Our study indicates that Mg based orthopaedic medical device may be considered for use in CRF patients without biosafety concerns |
| 收录类别 | SCI |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pubmed/27210744 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10515]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | SCIENTIFIC REPORTS |
| 推荐引用方式 GB/T 7714 | Wang, Jiali,Xu, Jiankun,Liu, Waiching,et al. Biodegradable Magnesium (Mg) Implantation Does Not Impose Related Metabolic Disorders in Rats with Chronic Renal Failure[J]. SCIENTIFIC REPORTS,2016. |
| APA | Wang, Jiali,Xu, Jiankun,Liu, Waiching,Li, Yangde,&Qin, Ling.(2016).Biodegradable Magnesium (Mg) Implantation Does Not Impose Related Metabolic Disorders in Rats with Chronic Renal Failure.SCIENTIFIC REPORTS. |
| MLA | Wang, Jiali,et al."Biodegradable Magnesium (Mg) Implantation Does Not Impose Related Metabolic Disorders in Rats with Chronic Renal Failure".SCIENTIFIC REPORTS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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