Anti-Inflammatory Oleanolic Triterpenes from Chinese Acorns
文献类型：期刊论文
| 作者 | Huang, Jie; Wang, Yihai; Li, Chuan; Wang, Xinluan; He, Xiangjiu |
| 刊名 | MOLECULES
 |
| 出版日期 | 2016 |
| 英文摘要 | Acorns play an important role in human history and are a source of food and recipes for many cultures around the world. In this study, eleven oleanolic triterpenes, one of which was novel, were isolated from Chinese acorns (Quercus serrata var. brevipetiolata). The chemical structure of the novel triterpene, which was identified as 2 alpha, 3 beta,19 alpha-trihydroxy-24-oxo-olean-12-en-28-oic acid (1), was established based on the interpretation of chemical and spectroscopic analyses, including IR, HR-ESI-MS, and NMR experiments (H-1, C-13 NMR, DEPT, H-1-H-1 COSY, HSQC, HMBC, and NOESY). All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages. Compared with the positive control drug indomethacin (IC50 = 47.4 mu M), compounds 1, 3, 6 and 8 exhibited remarkable anti-inflammatory activities with IC50 values of 5.4, 7.8, 4.0 and 8.9 mu M, respectively. Besides, compounds 2, 4, 7 and 9 also showed moderate anti-inflammatory activities with IC50 values of 10.1, 13.0, 20.1 and 17.2 mu M, respectively. Furthermore, Compound 1 could inhibit TNF-alpha-induced IL-6 and IL-8 production in MH7A cells. |
| 收录类别 | SCI |
| 原文出处 | http://www.mdpi.com/1420-3049/21/5/669/htm |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10524]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | MOLECULES |
| 推荐引用方式 GB/T 7714 | Huang, Jie,Wang, Yihai,Li, Chuan,et al. Anti-Inflammatory Oleanolic Triterpenes from Chinese Acorns[J]. MOLECULES,2016. |
| APA | Huang, Jie,Wang, Yihai,Li, Chuan,Wang, Xinluan,&He, Xiangjiu.(2016).Anti-Inflammatory Oleanolic Triterpenes from Chinese Acorns.MOLECULES. |
| MLA | Huang, Jie,et al."Anti-Inflammatory Oleanolic Triterpenes from Chinese Acorns".MOLECULES (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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