中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Triterpenes isolated from acorns of Quercus serrata var. brevipetiolata exert anti-inflammatory activity.

文献类型:期刊论文

作者Huang, Jie; Wang, Yihai; Li, Chuan; Wang, Xinluan; He, Xiangjiu
刊名INDUSTRIAL CROPS AND PRODUCTS
出版日期2016
英文摘要Acorns serve as an important role as an important cash crop in human history and are a source of food for many countries. In this study, ten pentacyclic triterpenes, three of which were novel, were isolated from acorns (Quercus serrata var. brevipetiolata). The structures of novel triterpenoids were established based on the interpretation of chemical and spectroscopic analyses, including IR, HR-ESI-MS, and NMR experiments (1D and 2D NMR), which were elucidated to be 3,2-3-O-methyl butyrate-2 alpha,3 beta,19 alpha,23-tetrahydroxy-urs-12-en-28-oic acid beta-D-glucopyranosyl ester (1), 3,23-O-methyl butyrate-2 alpha,3 beta,19 alpha,23-tetrahydroxy-olean-12-en-28-oic acid P-D-glucopyranosyl ester (2), and 23-acetoxy-2 alpha,3 alpha,19 alpha-trihydroxyurs-12-en-28-oic acid (3), respectively. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages. Most of the triterpenes from acorns showed pronounced anti-inflammatory activities compared to positive control indomethacin. Furthermore, based on the results of the nitric oxide assay, production of pro-inflammatory markers including interleukin-6 (IL-6) and interleukin-8 (IL-8) of compound 1-3 in TNF-alpha stimulated RAW 264.7 were investigated by ELISA, which showed these pentacyclic triterpenes may be responsible with the two pro-inflammatory cytokines for the anti-inflammatory activity of acorn. (C) 2016 Elsevier B.V. All rights reserved.
收录类别SCI
原文出处http://www.sciencedirect.com/science/article/pii/S0926669016304824
语种英语
源URL[http://ir.siat.ac.cn:8080/handle/172644/10525]  
专题深圳先进技术研究院_医工所
作者单位INDUSTRIAL CROPS AND PRODUCTS
推荐引用方式
GB/T 7714
Huang, Jie,Wang, Yihai,Li, Chuan,et al. Triterpenes isolated from acorns of Quercus serrata var. brevipetiolata exert anti-inflammatory activity.[J]. INDUSTRIAL CROPS AND PRODUCTS,2016.
APA Huang, Jie,Wang, Yihai,Li, Chuan,Wang, Xinluan,&He, Xiangjiu.(2016).Triterpenes isolated from acorns of Quercus serrata var. brevipetiolata exert anti-inflammatory activity..INDUSTRIAL CROPS AND PRODUCTS.
MLA Huang, Jie,et al."Triterpenes isolated from acorns of Quercus serrata var. brevipetiolata exert anti-inflammatory activity.".INDUSTRIAL CROPS AND PRODUCTS (2016).

入库方式: OAI收割

来源:深圳先进技术研究院

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。