Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats
文献类型：期刊论文
| 作者 | Mu Shuhua; OuYang Lisi; Liu Bingbing; Zhu Yaxi; Li Keyi; Zhan Mali; Liu Zongwei; Jia Yu; Lei Wanlong |
| 刊名 | Neurochemistry International
 |
| 出版日期 | 2011 |
| 卷号 | 59期号:2页码:224-234 |
| 英文摘要 | To confirm the effect of melatonin on 3-nitropropionic acid (3-NP)-induced striatal interneuron injury in rats, behavioral test, histology, immunohistochemistry and Western blotting were respectively used to characterize the behavioral changes of experimental animals in motor and cognition, the morphological changes of striatal interneurons and the expression level of protein markers induced by 3-NP. The results showed that (1) 3-NP induced dysfunction ofexperimental animals in movement, motor coordination and cognition could be relieved by melatonin treatment; (2) The 3-NP-induced lesion area was unvaryingly in dorsolateral striatum, with almost all neuronal loss in the lesion core, however, lots of neurons survived after melatonin treatment; (3) Immunohistochemical staining of the four interneuron types (parvalbu-minergic, cholinergic, calretinergic, and neuropeptide Y-neuronal nitric oxide synthase co-containing) showed that, in the lesion core of 3-NP group, loss of the four interneuron types was obvious, but in transition zone, the processes and varicositiesof calretinergic, and neuropeptide Y-neuronal nitric oxide synthase co-containing interneurons increased significantly. Melatonin treatment reduced the loss ofthe four interneuron types in the lesion core, and inhibited the increase of processes and varicosities in the transition zone; (4) Consistent with above results, the expression level of five interneuron protein markers were significantly increased in the striatum after melatonin treatment. Notably, in both the transition zone and the lesion core induced by 3-NP, TUNEL-positive cells were detected, but decreased significantly after melatonin treatment. The present results indicate that melatonin effectively protects the striatal neurons against the injury induced by 3-NP in rats. (C) 2011 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0197018611001835 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/3642]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Neurochemistry International |
| 推荐引用方式 GB/T 7714 | Mu Shuhua,OuYang Lisi,Liu Bingbing,et al. Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats[J]. Neurochemistry International,2011,59(2):224-234. |
| APA | Mu Shuhua.,OuYang Lisi.,Liu Bingbing.,Zhu Yaxi.,Li Keyi.,...&Lei Wanlong.(2011).Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats.Neurochemistry International,59(2),224-234. |
| MLA | Mu Shuhua,et al."Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats".Neurochemistry International 59.2(2011):224-234. |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。