Epigenetic disruption of cell signaling in nasopharyngeal carcinoma
文献类型：期刊论文
| 作者 | LiLi Li; XingSheng Shu; ZhaoHui Wang; Ya Cao; Qian Tao |
| 刊名 | Chinese journal of cancer癌症
 |
| 出版日期 | 2011 |
| 卷号 | 30期号:4页码:231-239 |
| 英文摘要 | Nasopharyngeal carcinoma (NPC) is a malignancy with remarkable ethnic and geographic distribution in southern China and Southeast Asia. Alternative to genetic changes, aberrant epigenetic events disrupt multiple genes involved in cell signaling pathways through DNA methylation of promoter CpG islands and/or histone modifications. These epigenetic alterations grant cell growth advantage and contribute to the initiation and progression of NPC. In this review, we summarize the epigenetic deregulation of cell signaling in NPC tumorigenesis and highlight the importance of identifying epigenetic cell signaling regulators in NPC research. Developing pharmacologic strategies to reverse the epigenetic-silencing of cell signaling regulators might thus be useful to NPC prevention and therapy. |
| 收录类别 | CSCD |
| 原文出处 | http://europepmc.org/articles/pmc4013349 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/3648]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Chinese journal of cancer癌症 |
| 推荐引用方式 GB/T 7714 | LiLi Li,XingSheng Shu,ZhaoHui Wang,et al. Epigenetic disruption of cell signaling in nasopharyngeal carcinoma[J]. Chinese journal of cancer癌症,2011,30(4):231-239. |
| APA | LiLi Li,XingSheng Shu,ZhaoHui Wang,Ya Cao,&Qian Tao.(2011).Epigenetic disruption of cell signaling in nasopharyngeal carcinoma.Chinese journal of cancer癌症,30(4),231-239. |
| MLA | LiLi Li,et al."Epigenetic disruption of cell signaling in nasopharyngeal carcinoma".Chinese journal of cancer癌症 30.4(2011):231-239. |
入库方式： OAI收割
来源：深圳先进技术研究院
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