A Novel 19q13 Nucleolar Zinc Finger Protein Suppresses Tumor Cell Growth through Inhibiting Ribosome Biogenesis and Inducing Apoptosis but Is Frequently Silenced in Multiple Carcinomas
文献类型：期刊论文
| 作者 | Cheng, Yingduan; Liang, Pei; Geng, Hua; Wang, Zhaohui; Li, Lili; Cheng, Suk Hang; Ying, Jianming; Su, Xianwei; Ka Man Ng; Ng, Margaret H. L. |
| 刊名 | MOLECULAR CANCER RESEARCH
 |
| 出版日期 | 2012 |
| 英文摘要 | Epigenetic disruption of tumor suppressor genes is frequently involved in tumorigenesis. We identified a novel 19q13 KRAB domain-containing zinc fingerprotein, ZNF545/ZFP82, broadly expressed in normal tissues but downregulated in multiple tumor cell lines. The ZNF545 promoter contains a CpG island, which is frequently methylated in cell lines. The transcriptional silencing of ZNF545 could be reversed by pharmacologic or genetic demethylation, indicating direct epigenetic silencing. ZNF545 was also frequently methylated in multiple primary tumors of nasopharyngeal, esophageal, lung, gastric, colon, and breast, but rarely in normal epithelial tissues and paired normal tissues. ZNF545 is located in the nucleus and mainly sequestered in nucleoli, functioning as arepressor. ZNF545 is able to repress NF-kappa B and AP-1 signaling pathways, whereas ectopic expression of ZNF545 in silenced tumor cells significantly inhibited their growth and induced apoptosis. Functional studies showed that ZNF545 was involved in ribosome biogenesis through inhibiting the activity of rDNA promoter and decreasing cellular protein translation efficiency. Thus, we identified ZNF545 as a novel tumor suppressor inducing tumor cell apoptosis, repressing ribosome biogenesis and target gene transcription. The tumor-specific methylation of ZNF545 could be an epigenetic biomarker for cancer diagnosis. Mol Cancer Res; 10(7); 925-36. (C) 2012 AACR. |
| 收录类别 | SCI |
| 原文出处 | http://mcr.aacrjournals.org/content/10/7/925 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4282]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | MOLECULAR CANCER RESEARCH |
| 推荐引用方式 GB/T 7714 | Cheng, Yingduan,Liang, Pei,Geng, Hua,et al. A Novel 19q13 Nucleolar Zinc Finger Protein Suppresses Tumor Cell Growth through Inhibiting Ribosome Biogenesis and Inducing Apoptosis but Is Frequently Silenced in Multiple Carcinomas[J]. MOLECULAR CANCER RESEARCH,2012. |
| APA | Cheng, Yingduan.,Liang, Pei.,Geng, Hua.,Wang, Zhaohui.,Li, Lili.,...&Tao, Qian.(2012).A Novel 19q13 Nucleolar Zinc Finger Protein Suppresses Tumor Cell Growth through Inhibiting Ribosome Biogenesis and Inducing Apoptosis but Is Frequently Silenced in Multiple Carcinomas.MOLECULAR CANCER RESEARCH. |
| MLA | Cheng, Yingduan,et al."A Novel 19q13 Nucleolar Zinc Finger Protein Suppresses Tumor Cell Growth through Inhibiting Ribosome Biogenesis and Inducing Apoptosis but Is Frequently Silenced in Multiple Carcinomas".MOLECULAR CANCER RESEARCH (2012). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。