Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging
文献类型：期刊论文
| 作者 | Zheng, Cuifang; Zheng, Mingbin; Gong, Ping; Jia, Dongxue; Zhang, Pengfei; Shi, Bihua; Sheng, Zonghai; Ma, Yifan; Cai, Lintao |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2012 |
| 英文摘要 | Indocyanine green (ICG) is a near-infrared (NIR) fluorescence dye for extensive biological application, but limited by its poor aqueous stability in vitro, concentration-dependent aggregation, rapid elimination from the body, and lack of target specificity. In this paper, to overcome these limitations, folate receptor-targeted, ICG dye-doped poly(D,L-lactide-co-glycolid) (PLGA) lipid nanoparticles (FA-ICG-PLGA-lipid NPs) were constructed by a single-step self-assemble and nanoprecipitation method. The prepared FA-ICG-PLGA-lipid NPs exhibited good biocompatibility, monodispersity, excellent NIR penetration ability, significant stability against photobleaching and long circulation time. The intracellular uptake experiment proved the targeting efficacy of the FA-ICG-PLGA-lipid NPs was more effective in folate receptor over-expressing MCF-7 cells than folate receptor negative A549 cells. Furthermore, the in vivoexperiments showed the FA-ICG-PLGA-lipid NPs were specifically targeted to the tumor, and its circulation time was much longer than free ICG. These biocompatible and biodegradable NIR-NPs prove a potential application in tumor diagnosis and targeted imaging due to its high aqueous stability, excellent NIR optical properties and significantly targeting property in vivo. (C) 2012 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0142961212004668 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4287]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOMACROMOLECULES |
| 推荐引用方式 GB/T 7714 | Zheng, Cuifang,Zheng, Mingbin,Gong, Ping,et al. Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging[J]. BIOMACROMOLECULES,2012. |
| APA | Zheng, Cuifang.,Zheng, Mingbin.,Gong, Ping.,Jia, Dongxue.,Zhang, Pengfei.,...&Cai, Lintao.(2012).Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging.BIOMACROMOLECULES. |
| MLA | Zheng, Cuifang,et al."Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging".BIOMACROMOLECULES (2012). |
入库方式： OAI收割
来源：深圳先进技术研究院
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