Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy
文献类型：期刊论文
| 作者 | Sheng, Zonghai; Song, Liang; Zheng, Jiaxiang; Hu, Dehong; He, Meng; Zheng, Mingbin; Gao, Guanhui; Gong, Ping; Zhang, Pengfei; Ma, Yifan |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2013 |
| 英文摘要 | Theranostic agents are attracting a great deal of attention in personalized medicine. Here, we developed a protein-based, facile method for fabrication ofnanosized, reduced graphene oxide (nano-rGO) with high stability and low cytotoxicity. We constructed highly integrated photoacoustic/ultrasonic dual-modality imaging and photothermal therapy platforms, and further demonstrated that the prepared nano-rGO can be used as ready-to-use theranostic agentsfor both photoacoustic imaging and photothermal therapy without further surface modification. Intravenous administration of nano-rGO in tumor-bearing mice showed rapid and significant photoacoustic signal enhancement in the tumor region, indicating its excellence for passive targeting and photoacoustic imaging. Meanwhile, using a continuous-wave near-infrared laser, cancer cells in vivo were efficiently ablated, due to the photothermal effect of nano-rGO. The results suggest that the nano-rGO with protein-assisted fabrication was well suited for photoacoustic imaging and photothermal therapy of tumor, which is promisingfor theranostic nanomedicine. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0142961213004249 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5142]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOMATERIALS |
| 推荐引用方式 GB/T 7714 | Sheng, Zonghai,Song, Liang,Zheng, Jiaxiang,et al. Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy[J]. BIOMATERIALS,2013. |
| APA | Sheng, Zonghai.,Song, Liang.,Zheng, Jiaxiang.,Hu, Dehong.,He, Meng.,...&Cai, Lintao.(2013).Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy.BIOMATERIALS. |
| MLA | Sheng, Zonghai,et al."Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy".BIOMATERIALS (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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