Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy
文献类型：期刊论文
| 作者 | Zheng, Cuifang; Zheng, Mingbin; Gong, Ping; Deng, Jizhe; Yi, Huqiang; Zhang, Pengfei; Zhang, Yijuan; Liu, Peng; Ma, Yifan; Cai, Lintao |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2013 |
| 英文摘要 | Combination of two or more therapeutic strategies with different mechanisms can cooperatively impede tumor growth. Co-delivery of chemotherapeutic drug and small interfering RNA (siRNA) within a single nanoparticle (NP) provides a rational strategy for combined cancer therapy. Here, we prepared polypeptide micelle nanoparticles (NPs) of a triblock copolymer poly(ethylene glycol)-b-poly(L-lysine)-b-poly(L-leucine) (PEG-PLL-PLLeu) to systemically codeliver docetaxel (DTX) and siRNA-Bcl-2 for an effective drug/gene vector. The hydrophobic PLLeu core entrapped with anticancer drugs, while the PLL polypeptide cationic backbone allowed for electrostatic interaction with the negatively charged siRNA. The resulting micelle NP exhibited very stable, good biocompatible and excellent passive targeted properties. The micelle complexes with siRNA-Bcl-2 effectively knocked down the expression of Bcl-2 mRNA and protein. Moreover, the co-delivery system of DTX and siRNA-Bcl-2 (DTX siRNA NPs) obviously down-regulation of the anti-apoptotic Bcl-2 gene and enhanced antitumor activity with a smaller dose of DTX, resulting the significantly inhibited tumor growth of MCF-7 xenograft murine model as compared to the individual siRNA and only DTX treatments. Our results demonstrated well-defined PEG-PLL-PLLeu polypeptide cationic micelles with the excellent synergistic effect of DTX and siRNA-Bcl-2 in combined cancer therapy. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0142961213000811 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5143]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOMATERIALS |
| 推荐引用方式 GB/T 7714 | Zheng, Cuifang,Zheng, Mingbin,Gong, Ping,et al. Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy[J]. BIOMATERIALS,2013. |
| APA | Zheng, Cuifang.,Zheng, Mingbin.,Gong, Ping.,Deng, Jizhe.,Yi, Huqiang.,...&Cai, Lintao.(2013).Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy.BIOMATERIALS. |
| MLA | Zheng, Cuifang,et al."Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy".BIOMATERIALS (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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