Hybrid polypeptide micelles loading indocyanine green for tumor imaging and photothermal effect study
文献类型：期刊论文
| 作者 | Wu, Lei; Fang, Shengtao; Shi, Shuai; Deng, Jizhe; Liu, Bin; Cai, Lintao |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2013 |
| 英文摘要 | Indocyanine green (ICG) is a near-infrared (NIR) fluorescence dye for extensive applications; however, it is limited for further biological application due to its poor aqueous stability in vitro, concentration-dependent aggregation, rapid elimination from the body, and lack of target specificity. To overcome its limitations, ICG was encapsulated in the core of a polymeric micelle, which self-assembled from amphiphilic PEG-polypeptide hybrid triblock copolymers of poly(ethylene glycol)-b-poly(L-lysine)-b-poly(L-leucine) (PEG-PLL-PLLeu), with PLLeu as the hydrophobic core and PEG as the hydrophilic shell. The ICG was associated with the hydrophobic core via hydrophobic interaction and also the hydrophilic heads through electrostatic attractive interaction. Compared with free ICG, PEG-PLL-PLLeu-ICG micelles significantly improved quantum yield and fluorescent stability. The cellular uptake experiments showed that PEG-PLL-PLLeu-ICGmicelles have a high cellular uptake rate. And the in vivo experiments revealed the excellent passive tumor targeting ability and long circulation time of PEG-PLL-PLLeu-ICG. The above results indicated the broad prospects of PEG-PLL-PLLeu-ICG application in the fields of tumor diagnosis and imaging. In addition, temperature measurements under NIR laser irradiation and in vitro photothermal ablation studies proved the potential application of PEG-PLL-PLLeu-ICG intumor photothermal therapy. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.acs.org/doi/abs/10.1021/bm400839b |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5159]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOMACROMOLECULES |
| 推荐引用方式 GB/T 7714 | Wu, Lei,Fang, Shengtao,Shi, Shuai,et al. Hybrid polypeptide micelles loading indocyanine green for tumor imaging and photothermal effect study[J]. BIOMACROMOLECULES,2013. |
| APA | Wu, Lei,Fang, Shengtao,Shi, Shuai,Deng, Jizhe,Liu, Bin,&Cai, Lintao.(2013).Hybrid polypeptide micelles loading indocyanine green for tumor imaging and photothermal effect study.BIOMACROMOLECULES. |
| MLA | Wu, Lei,et al."Hybrid polypeptide micelles loading indocyanine green for tumor imaging and photothermal effect study".BIOMACROMOLECULES (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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