Epigenetic silencing of WNT5A in Epstein-Barr virus-associated gastric carcinoma
文献类型：期刊论文
| 作者 | Xia Liu; Yun Wang; Xiaofeng Wang; Zhifu Sun; Lili Li; Qian Tao; Bing Luo |
| 刊名 | ARCHIVES OF VIROLOGY
 |
| 出版日期 | 2013 |
| 英文摘要 | Epstein-Barr virus (EBV) is responsible for the development of multiple tumors, including EBV-associated gastric carcinoma (EBVaGC), but little is known about its mechanisms in EBVaGC.WNT5A expression and promoter methylation were measured in 5 EBV-positive and 15 EBV-negative GC cell lines. The methylation status of 23 EBV-positive and 25 EBV-negative paired tumor/normal tissue samples was also examined. EBV-positive GC had no or very low expression ofWNT5A but a high level of methylation in the promoter region. In contrast, EBV-negative GC had higher WNT5A expression and a lower level of promoter methylation. The reduced WNT5Aexpression could be restored by treatment with Aza, a methyltransferase inhibitor. Increased expression of WNT5A in vitro inhibited β-catentin expression in EBVaGC cells (SNU719). These results suggest that hypermethylation of WNT5A induced by EBV may contribute to the development of EBVaGC. Ectopic introduction of WNT5A may have preventive/therapeutic potential for tumors with silenced WNT5A. |
| 收录类别 | SCI |
| 原文出处 | http://link.springer.com/article/10.1007%2Fs00705-012-1481-x |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5175]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | ARCHIVES OF VIROLOGY |
| 推荐引用方式 GB/T 7714 | Xia Liu,Yun Wang,Xiaofeng Wang,et al. Epigenetic silencing of WNT5A in Epstein-Barr virus-associated gastric carcinoma[J]. ARCHIVES OF VIROLOGY,2013. |
| APA | Xia Liu.,Yun Wang.,Xiaofeng Wang.,Zhifu Sun.,Lili Li.,...&Bing Luo.(2013).Epigenetic silencing of WNT5A in Epstein-Barr virus-associated gastric carcinoma.ARCHIVES OF VIROLOGY. |
| MLA | Xia Liu,et al."Epigenetic silencing of WNT5A in Epstein-Barr virus-associated gastric carcinoma".ARCHIVES OF VIROLOGY (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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