Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy
文献类型：期刊论文
| 作者 | Jia Xiao; Rui Guo; Man-Lung Fung; Emily C. Liong; Raymond Chuen Chung Chang; Yick-Pang Ching; George L. Tipoe |
| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2013 |
| 英文摘要 | Our previous study demonstrated that administration of garlic-derived antioxidant S-allylmercaptocysteine (SAMC) ameliorated hepatic injury in a nonalcoholic fatty liver disease (NAFLD) rat model. Our present study aimed to investigate the mechanism of SAMC on NAFLD-induced hepatic apoptosis and autophagy. Adult female rats were fed with a high-fat diet for 8 weeks to develop NAFLD with or without intraperitoneal injection of 200 mg/kg SAMC for three times per week. During NAFLD development, increased apoptotic cells and caspase-3 activation were observed in the liver. Increased apoptosis was modulated through both intrinsic and extrinsic apoptotic pathways. NAFLD treatment also enhanced the expression of key autophagic markers in the liver with reduced activity of LKB1/AMPK and PI3K/Akt pathways. Increased expression of proapoptotic regulator p53 and decreased activity of antiautophagic regulator mTOR were also observed. Administration of SAMC reduced the number of apoptotic cells through downregulation of both intrinsic and extrinsic apoptotic mechanisms. SAMC also counteracted the effects of NAFLD on LKB1/AMPK and PI3K/Akt pathways. Treatment with SAMC further enhanced hepatic autophagy by regulating autophagic markers and mTOR activity. In conclusion, administration of SAMC during NAFLD development in rats protects the liver from chronic injury by reducing apoptosis and enhancing autophagy. |
| 收录类别 | SCI |
| 原文出处 | http://www.hindawi.com/journals/ecam/2013/642920/ |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5180]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE |
| 推荐引用方式 GB/T 7714 | Jia Xiao,Rui Guo,Man-Lung Fung,et al. Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013. |
| APA | Jia Xiao.,Rui Guo.,Man-Lung Fung.,Emily C. Liong.,Raymond Chuen Chung Chang.,...&George L. Tipoe.(2013).Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. |
| MLA | Jia Xiao,et al."Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。