热门
Functionalized quantum dots induce proinflammatory responses in vitro: the role of terminal functional group-associated endocytic pathways
文献类型：期刊论文
| 作者 | Zhang, Yijuan; Pan, Hong; Zhang, Pengfei; Gao, Ningning; Lin, Yi; Luo, Zichao; Li, Ping; Wang, Ce; Liu, Lanlan; Pang, Daiwen |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2013 |
| 英文摘要 | PEGylation has been applied as an effective strategy of surface functionalization to improve the stability and reduce non-specific binding of quantum dots(QDs). However, its effects on the proinflammatory properties of QDs and the underlying mechanism have not been well elucidated yet. Herein, theproinflammatory effects of PEGylated CdSe/ZnS QDs with an amphiphilic polymer coating (PEG-pQDs) were investigated in human pulmonary epithelial cells and macrophages by evaluating the cytokine/chemokine production. The results showed that the proinflammatory effects of PEG-pQDs were stronglyassociated with the functional groups (-COOH, -NH2, -OH, and -OCH3) at the end of PEG chain. COOH-PEG-pQDs demonstrated the most proinflammatoryeffects followed by NH2-PEG-pQDs and HO-PEG-pQDs with CH3O-PEG-pQDs exhibiting the least proinflammatory effects. The proinflammatory effects ofPEG-pQDs relied on lipid raft-and class A scavenger receptor (SRA)-dependent endocytic pathways as well as the downstream NF-kappa B and MAPK signaling cascades. COOH-PEG-pQDs were selectively internalized by lipid raft-and SRA-mediated endocytosis, which consequently activated NF-kappa B signaling pathway. On the other hand, NH2-PEG-pQDs and HO-PEG-pQDs were mostly internalized via lipid raft-mediated endocytosis, thereby activating p38 MAPK/AP-1 signaling cascades. These data revealed a critical role of terminal functional group-associated endocytic pathways in the proinflammatoryresponses induced by PEGylated QDs in human pulmonary epithelial cells and macrophages. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.rsc.org/en/content/articlehtml/2013/nr/c3nr01653f |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5189]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | NANOSCALE |
| 推荐引用方式 GB/T 7714 | Zhang, Yijuan,Pan, Hong,Zhang, Pengfei,et al. Functionalized quantum dots induce proinflammatory responses in vitro: the role of terminal functional group-associated endocytic pathways[J]. NANOSCALE,2013. |
| APA | Zhang, Yijuan.,Pan, Hong.,Zhang, Pengfei.,Gao, Ningning.,Lin, Yi.,...&Ma, Yifan.(2013).Functionalized quantum dots induce proinflammatory responses in vitro: the role of terminal functional group-associated endocytic pathways.NANOSCALE. |
| MLA | Zhang, Yijuan,et al."Functionalized quantum dots induce proinflammatory responses in vitro: the role of terminal functional group-associated endocytic pathways".NANOSCALE (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。