Single-step assembly of DOX/ICG loaded lipid–polymer nanoparticles for highly effective chemo-photothermal combination therapy
文献类型：期刊论文
| 作者 | Zheng, Mingbin; Yue, Caixia; Ma, Yifan; Gong, Ping; Zhao, Pengfei; Zheng, Cuifang; Sheng, Zonghai; Zhang, Pengfei; Wang, Zhaohui; Cai, Lintao |
| 刊名 | ACS NANO
 |
| 出版日期 | 2013 |
| 英文摘要 | A combination of chemotherapy and photothermal therapy has emerged as a promising strategy for cancer therapy. To ensure the chemotherapeutic drug andphotothermal agent could be simultaneously delivered to a tumor region to exert their synergistic effect, a safe and efficient delivery system is highly desirable. Herein, we fabricated doxorubicin (DOX) and indocyanine green (ICG) loaded poly(lactic-co-glycolic acid) (PLGA) lecithin polyethylene glycol (PEG)nanoparticles (DINPs) using a single-step sonication method. The DINPs exhibited good monodispersity, excellent fluorescence/size stability, and consistent spectra characteristics compared with free ICG or DOX. Moreover, the DINPs showed higher temperature response, faster DOX release under laser irradiation, and longer retention time in tumor. In the meantime, the fluorescence of DOX and ICG in DINPs was also visualized for the process of subcellular location in vitro and metabolic distribution in vivo. In comparison with chemo or photothermal treatment alone, the combined treatment of DINPs with laser irradiation synergistically induced the apoptosis and death of DOX-sensitive MCF-7 and DOX-resistant MCF-7/ADR cells, and suppressed MCF-7 and MCF-7/ADR tumor growth in vivo. Notably, no tumor recurrence was observed after only a single dose of DINPs with laser irradiation. Hence, the well-defined DINPs exhibited great potential in targeting cancer imaging and chemo-photothermal therapy. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.acs.org/doi/abs/10.1021/nn400334y |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5190]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | ACS NANO |
| 推荐引用方式 GB/T 7714 | Zheng, Mingbin,Yue, Caixia,Ma, Yifan,et al. Single-step assembly of DOX/ICG loaded lipid–polymer nanoparticles for highly effective chemo-photothermal combination therapy[J]. ACS NANO,2013. |
| APA | Zheng, Mingbin.,Yue, Caixia.,Ma, Yifan.,Gong, Ping.,Zhao, Pengfei.,...&Cai, Lintao.(2013).Single-step assembly of DOX/ICG loaded lipid–polymer nanoparticles for highly effective chemo-photothermal combination therapy.ACS NANO. |
| MLA | Zheng, Mingbin,et al."Single-step assembly of DOX/ICG loaded lipid–polymer nanoparticles for highly effective chemo-photothermal combination therapy".ACS NANO (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。