Intermedin attenuates LPS-induced inflammation in the rat testis
文献类型：期刊论文
| 作者 | Li, Lei; Ma, Ping; Liu, Yongjun; Huang, Chen; O, Wai-sum; Tang, Fai; Zhang, Jian V. |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013 |
| 英文摘要 | First reported as a vasoactive peptide in the cardiovascular system, intermedin (IMD), also known as adrenomedullin 2 (ADM2), is a hormone with multiple potent roles, including its antioxidant action on the pulmonary, central nervous, cardiovascular and renal systems. Though IMD may play certain roles introphoblast cell invasion, early embryonic development and cumulus cell-oocyte interaction, the role of IMD in the male reproductive system has yet to be investigated. This paper reports our findings on the gene expression of IMD, its receptor components and its protein localization in the testes. In a rat model, bacterial lippolysaccharide (LPS) induced atypical orchitis, and LPS treatment upregulated the expression of IMD and one of its receptor component proteins, i.e. receptor activity modifying protein 2 (RAMP2). IMD decreased both plasma and testicular levels of reactive oxygen species (ROS) production, attenuatedthe increase in the gene expression of the proinflammatory cytokines tumor necrosis factor alpha (TNF alpha), interleukin 6 (IL6) and interleukin 1 beta (IL1 beta), rescued spermatogenesis, and prevented the decrease in plasma testosterone levels caused by LPS. The restorative effect of IMD on steroidogenesis was also observed in hydrogen peroxide-treated rat primary Leydig cells culture. Our results indicate IMD plays an important protective role in spermatogenesis and steroidogenesis, suggesting therapeutic potential for IMD in pathological conditions such as orchitis. |
| 收录类别 | SCI |
| 原文出处 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065278 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5193]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | PLOS ONE |
| 推荐引用方式 GB/T 7714 | Li, Lei,Ma, Ping,Liu, Yongjun,et al. Intermedin attenuates LPS-induced inflammation in the rat testis[J]. PLOS ONE,2013. |
| APA | Li, Lei.,Ma, Ping.,Liu, Yongjun.,Huang, Chen.,O, Wai-sum.,...&Zhang, Jian V..(2013).Intermedin attenuates LPS-induced inflammation in the rat testis.PLOS ONE. |
| MLA | Li, Lei,et al."Intermedin attenuates LPS-induced inflammation in the rat testis".PLOS ONE (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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