Expression of chemerin and its receptors in rat testes and its action on testosterone secretion
文献类型：期刊论文
| 作者 | Li, Lei; Ma, Ping; Huang, Chen; Liu, Yongjun; Zhang, Ye; Gao, Chen; Xiao, Tianxia; Ren, Pei-Gen; Zabel, Brian A.; Zhang, Jian V. |
| 刊名 | JOURNAL OF ENDOCRINOLOGY
 |
| 出版日期 | 2014 |
| 英文摘要 | The novel adipokine chemerin plays a role in the regulation of lipid and carbohydrate metabolism, and recent reports of elevated chemerin levels in polycystic ovarian syndrome and preeclampsia have pointed to an emerging role of chemerin in reproduction. We hypothesised that chemerin, like other adipokines, may function to regulate male gonadal steroidogenesis. In this study, we show that chemerin and its three receptors chemokine-like receptor 1 (CMKLR1), G-protein-coupled receptor 1 (GPR1) and chemokine (C-C motif) receptor-like 2 were expressed in male reproductive tracts, liver and white adipose tissue. CMKLR1 and GPR1 proteins were localised specifically in the Leydig cells of human and rat testes by immunohistochemistry. The expression of chemerin andits receptors in rat testes was developmentally regulated and highly expressed in Leydig cells. In vitro treatment with chemerin suppressed the human chorionic gonadotropin (hCG)-induced testosterone production from primary Leydig cells, which was accompanied by the inhibition of 3 beta-hydroxysteroid dehydrogenase gene and protein expression. The hCG-activated p44/42 MAPK (Erk1/2) pathway in Leydig cells was also inhibited by chemerin cotreatment. Together, these data suggest that chemerin is a novel regulator of male gonadal steroidogenesis. |
| 收录类别 | SCI |
| 原文出处 | http://joe.endocrinology-journals.org/content/220/2/155.short |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6080]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | JOURNAL OF ENDOCRINOLOGY |
| 推荐引用方式 GB/T 7714 | Li, Lei,Ma, Ping,Huang, Chen,et al. Expression of chemerin and its receptors in rat testes and its action on testosterone secretion[J]. JOURNAL OF ENDOCRINOLOGY,2014. |
| APA | Li, Lei.,Ma, Ping.,Huang, Chen.,Liu, Yongjun.,Zhang, Ye.,...&Zhang, Jian V..(2014).Expression of chemerin and its receptors in rat testes and its action on testosterone secretion.JOURNAL OF ENDOCRINOLOGY. |
| MLA | Li, Lei,et al."Expression of chemerin and its receptors in rat testes and its action on testosterone secretion".JOURNAL OF ENDOCRINOLOGY (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。