MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2
文献类型：期刊论文
| 作者 | Ruan, Q.; Wang, P.; Wang, T.; Qi, J.; Wei, M.; Wang, S.; Fan, T.; Johnson, D.; Wan, X.; Shi, W.Sun, H. |
| 刊名 | CELL DEATH & DISEASE
 |
| 出版日期 | 2014 |
| 英文摘要 | MicroRNAs (MiRs) are short noncoding RNAs that can regulate gene expression. It has been reported that miR-21 suppresses apoptosis in activated T cells, but the molecular mechanism remains undefined. Tumor suppressor Tipe2 (or tumor necrosis factor-a-induced protein 8 (TNFAIP8)-like 2 (TNFAIP8L2)) is a newly identified anti-inflammatory protein of the TNFAIP8 family that is essential for maintaining immune homeostasis. We report here that miR-21 is a direct target of nuclear factor-kappa B and could regulate Tipe2 expression in a Tipe2 coding region-dependent manner. In activated T cells and macrophages, Tipe2expression was markedly downregulated, whereas miR-21 expression was upregulated. Importantly, Tipe2-deficient T cells were significantly less sensitive toapoptosis. Conversely, overexpression of Tipe2 in EL-4 T cells increased their susceptibility to activation-induced apoptosis. Therefore, Tipe2 provides a molecular bridge between miR-21 and cell apoptosis; miR-21 suppresses apoptosis in activated T cells at least in part through directly targeting tumorsuppressor gene Tipe2. |
| 收录类别 | SCI |
| 原文出处 | http://www.nature.com/cddis/journal/v5/n2/full/cddis201447a.html |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6084]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | CELL DEATH & DISEASE |
| 推荐引用方式 GB/T 7714 | Ruan, Q.,Wang, P.,Wang, T.,et al. MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2[J]. CELL DEATH & DISEASE,2014. |
| APA | Ruan, Q..,Wang, P..,Wang, T..,Qi, J..,Wei, M..,...&Chen, Y. H..(2014).MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2.CELL DEATH & DISEASE. |
| MLA | Ruan, Q.,et al."MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2".CELL DEATH & DISEASE (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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