Piperazine-based polyurethane-ureas with controllable degradation as potential bone scaffolds
文献类型：期刊论文
| 作者 | Ruan, Changshun; Hu, Nan; Hu, Yang; Jiang, Lixin; Cai, Qingqing; Wang, Huaiyu; Pan, Haobo; Lu, William W.; Wang, Yuanliang |
| 刊名 | POLYMER
 |
| 出版日期 | 2014 |
| 英文摘要 | Piperazine-based polyurethane ureas (P-PUUs) with piperazine (PP) units as the functional ingredients have been designed to explore a novel polymeric biomaterial with the controllable degradation for bone repair in this study. P-PUUs were prepared upon the chain-growth polymerization of poly (D, L -lactic acid) diol (PDLLA diol), 1, 6-hexamethylene diisocyanate (HDI) where PP functioned as the chain extender. The investigation of in vitro degradation of P-PUUs was performed and the mechanical properties of P-PUUs during degradation were calculated. The results revealed that manipulating the ratio of PDLLA diol: HDI: PP could obtain the precise number of PP units (Num(pp)) in P-PUUs which may significantly impact the degradation stability and the degradation rate of P-PUUs. The negative linear correlation between the degradation rate and the Num(pp) of P-PUUs has been proved, suggesting the P-PUUs were endowedwith controllable degradation. Such a linear correlation is expected to be applied to bone repair where the specific degradation rate of P-PUUs for the specificbone defect can be precisely predicted once the Num(pp) and the bone repairing period are known. Additionally, P-PUUs with higher Num(pp) exhibited remarkable mechanical properties during degradation which allowed polymers to provide more persistent mechanical support to bone repair. (C) 2014 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0032386114000263?np=y |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6092]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | POLYMER |
| 推荐引用方式 GB/T 7714 | Ruan, Changshun,Hu, Nan,Hu, Yang,et al. Piperazine-based polyurethane-ureas with controllable degradation as potential bone scaffolds[J]. POLYMER,2014. |
| APA | Ruan, Changshun.,Hu, Nan.,Hu, Yang.,Jiang, Lixin.,Cai, Qingqing.,...&Wang, Yuanliang.(2014).Piperazine-based polyurethane-ureas with controllable degradation as potential bone scaffolds.POLYMER. |
| MLA | Ruan, Changshun,et al."Piperazine-based polyurethane-ureas with controllable degradation as potential bone scaffolds".POLYMER (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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