Tunable Degradation of Piperazine-Based Polyurethane Ureas
文献类型：期刊论文
| 作者 | Ruan, Changshun; Hu, Yang; Jiang, Lixin; Cai, Qingqing; Pan, Haobo; Wang, Huaiyu |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2014 |
| 英文摘要 | To manipulate the degradation of polymeric biomaterial for potential applications in tissue regeneration, a series of piperazinebased polyurethane ureas (P-PUUs) were designed and prepared with poly(D, L-lactic acid) diol (PDLLA diol), 1,6-hexamethylene diisocyanate (HDI), and piperazine (PP). The number ofpiperazine units [Num(pp)] in the P-PUUs could be precisely calculated by a specified equation and could be controlled by the regulation of the PDLLA diol/HDI/PP ratio. Then, the in vitro degradation of the P-PUUs was investigated by the detection of the variation of the pH value, the weight loss ratio, the surface morphologies, and the molecular weight loss over 12 weeks. The results reveal that the degradation stability and the degradation rate of the P-PUUs could be manipulated by Num(pp), and a linear correlation between the degradation rate of the P-PUUs and Num(pp) in the polymer was demonstrated; this implied the tunable degradation of the P-PUUs. Such a linear correlation is expected to benefit to tissue regeneration as the degradation rate of P-PUUs for specific tissue defects can be well tuned once the tissue regenerative period is known. (C) 2014 Wiley Periodicals, Inc. This article is part of a Special Issue on Bioactive Surface Functionalization. The remaining articles appear in J. Appl. Polym. Sci. (2014) volume 131, issue 14. This note was added on 14th July 2014. |
| 收录类别 | SCI |
| 原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/app.40527/abstract;jsessionid=BECB212863207D9ECF13BD2CE67B92F1.f04t03 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6093]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | JOURNAL OF APPLIED POLYMER SCIENCE |
| 推荐引用方式 GB/T 7714 | Ruan, Changshun,Hu, Yang,Jiang, Lixin,et al. Tunable Degradation of Piperazine-Based Polyurethane Ureas[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2014. |
| APA | Ruan, Changshun,Hu, Yang,Jiang, Lixin,Cai, Qingqing,Pan, Haobo,&Wang, Huaiyu.(2014).Tunable Degradation of Piperazine-Based Polyurethane Ureas.JOURNAL OF APPLIED POLYMER SCIENCE. |
| MLA | Ruan, Changshun,et al."Tunable Degradation of Piperazine-Based Polyurethane Ureas".JOURNAL OF APPLIED POLYMER SCIENCE (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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