In search of nucleus pulposus-specific molecular markers
文献类型：期刊论文
| 作者 | Lv Fengjuan; Leung Victor Y. L.; Huang Shishu; Huang Yongcan; Sun Yi; Cheung Kenneth M. C. |
| 刊名 | RHEUMATOLOGY
 |
| 出版日期 | 2014 |
| 英文摘要 | Intervertebral disc degeneration usually starts from the inner nucleus pulposus (NP). The majority of previous NP-related studies assessed the outcome by the expression of chondrogenic markers since NP cells are chondrocyte like. However, NP cells are unique from chondrocytes and such assessments may be inappropriate. Very recently, several investigators published their findings about the transcriptional differences between NP cells and other related cell types on a genomic scale. In this review we discuss these recent findings and summarize the molecules that may be utilized as NP-specific markers to distinguish normal NP cells from several cell types and as markers that indicate its degeneration. We will revisit markers that distinguish NP cells from the outer surrounding annulus fibrosus (AF) cells and articular chondrocytes so as to facilitate authentic NP cell engineering from stem cells. Our review indicated that N-cadherin and keratin 19 have the potential to serve as common NP markers, as they distinguish healthy NP cells from AF cells, articular cartilage cells and degenerated NP cells. |
| 收录类别 | SCI |
| 原文出处 | http://rheumatology.oxfordjournals.org/content/53/4/600 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6104]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | RHEUMATOLOGY |
| 推荐引用方式 GB/T 7714 | Lv Fengjuan,Leung Victor Y. L.,Huang Shishu,et al. In search of nucleus pulposus-specific molecular markers[J]. RHEUMATOLOGY,2014. |
| APA | Lv Fengjuan,Leung Victor Y. L.,Huang Shishu,Huang Yongcan,Sun Yi,&Cheung Kenneth M. C..(2014).In search of nucleus pulposus-specific molecular markers.RHEUMATOLOGY. |
| MLA | Lv Fengjuan,et al."In search of nucleus pulposus-specific molecular markers".RHEUMATOLOGY (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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