Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance
文献类型：期刊论文
| 作者 | Zhu, Huijun; Chen, Hongbo; Zeng, Xiaowei; Wang, Zhongyuan; Zhang, Xudong; Wu, Yanping; Gao, Yongfeng; Zhang, Jinxie; Liu, Kewei; Liu, Ranyi |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2014 |
| 英文摘要 | We report a strategy to make use of poly(lactic-co-glycolic acid) nanoparticle (PLGA NPs) for co-delivery of docetaxel (DTX) as a model anticancer drugtogether with vitamin E TPGS. The latter plays a dual role as a pore-forming agent in the nanopartides that may result in smaller particle size, higher drugencapsulation efficiency and faster drug release, and also as a bioactive agent that could inhibit P-glycoprotein to overcome multi-drug resistance of the cancer cells, The DTX-loaded PLGA NPs of 0, 10, 20 and 40% TPGS were prepared by the nanoprecipitation method and then characterized for their size and size distribution, surface morphology, physical status and encapsulation efficiency of the drug in the NPs. All four NPs were found of size ranged 100-120 nm and EE ranged 85-95% at drug loading level around 10%. The in vitro evaluation showed that the 48 h IC50 values of the free DTX and the DTX-loaded PLGA NPs of0, 10,20% TPGS were 2.619 and 0.474, 0.040, 0.009 mu g/mL respectively, which means that the PLGA NPs formulation could be 5.57 fold effective than the free DTX and that the DTX-loaded PLGA NPs of 10 or 20% TPGS further be 11.85 and 52.7 fold effective than the DTX-loaded PLGA NPs of no TPGS(therefore, 66.0 and 284 fold effective than the free DTX). Xenograft tumor model and immunohistological staining analysis further confirmed the advantages ofthe strategy of co-delivery of anticancer drugs with TPGS by PLGA NPs. (c) 2013 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S014296121301452X |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6118]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOMATERIALS |
| 推荐引用方式 GB/T 7714 | Zhu, Huijun,Chen, Hongbo,Zeng, Xiaowei,et al. Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance[J]. BIOMATERIALS,2014. |
| APA | Zhu, Huijun.,Chen, Hongbo.,Zeng, Xiaowei.,Wang, Zhongyuan.,Zhang, Xudong.,...&Feng, Si-Shen.(2014).Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance.BIOMATERIALS. |
| MLA | Zhu, Huijun,et al."Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance".BIOMATERIALS (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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