Folate Receptor-Targeting Gold Nanoclusters as Fluorescence Enzyme Mimetic Nanoprobes for Tumor Molecular Colocalization Diagnosis
文献类型：期刊论文
| 作者 | Hu, Dehong; Sheng, Zonghai; Fang, Shengtao; Wang, Yanan; Gao, Duyang; Zhang, Pengfei; Gong, Ping; Ma, Yifan; Cai, Lintao |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2014 |
| 英文摘要 | Nanoprobes with enzyme-like properties attracted a growing interest in early screening and diagnosis of cancer. To achieve high accuracy and specificity oftumor detection, the design and preparation of enzyme mimetic nanoprobes with high enzyme activity, tumor targeting and excellent luminescence property is highly desirable. Herein, we described a novel kind of fluorescence enzyme mimetic nanoprobe based on folate receptor-targeting Au nanoclusters. Thenanoprobes exhibited excellent stability, low cytotoxicity, high fluorescence and enzyme activity. We demonstrated that the nanoprobes could be used fortumor tissues fluorescence/visualizing detection. For the same tumor tissue slice, the nanoprobes peroxidase staining and fluorescent staining were obtained simultaneously, and the results were mutually complementary. Therefore, the fluorescence enzyme mimetic nanoprobes could provide a molecularcolocalization diagnosis strategy, efficiently avoid false-positive and false-negative results, and further improve the accuracy and specificity of cancer diagnoses. By examining different clinical samples, we demonstrated that the nanoprobes could distinguish efficiently cancerous cells from normal cells, and exhibit a clinical potential for cancer diagnosis. |
| 收录类别 | SCI |
| 原文出处 | http://www.thno.org/v04p0142.htm |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6120]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | THERANOSTICS |
| 推荐引用方式 GB/T 7714 | Hu, Dehong,Sheng, Zonghai,Fang, Shengtao,et al. Folate Receptor-Targeting Gold Nanoclusters as Fluorescence Enzyme Mimetic Nanoprobes for Tumor Molecular Colocalization Diagnosis[J]. THERANOSTICS,2014. |
| APA | Hu, Dehong.,Sheng, Zonghai.,Fang, Shengtao.,Wang, Yanan.,Gao, Duyang.,...&Cai, Lintao.(2014).Folate Receptor-Targeting Gold Nanoclusters as Fluorescence Enzyme Mimetic Nanoprobes for Tumor Molecular Colocalization Diagnosis.THERANOSTICS. |
| MLA | Hu, Dehong,et al."Folate Receptor-Targeting Gold Nanoclusters as Fluorescence Enzyme Mimetic Nanoprobes for Tumor Molecular Colocalization Diagnosis".THERANOSTICS (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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