Multifunctional Layered Gadolinium Hydroxide Nanoplates for Ultrahigh Field Magnetic Resonance Imaging, Computed Tomography and Fluorescence Bioimaging
文献类型：期刊论文
| 作者 | Wu, Min; Li, Lei; Yu, Xuefeng; Zhang, Daquan; Sun, Tianying; Li, Xue; Sun, Ling; Lui, Su; Huang, Xiaoqi; Bi, Feng |
| 刊名 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
 |
| 出版日期 | 2014 |
| 英文摘要 | The commonly used clinical magnetic resonance imaging (MRI) contrast agents are generally suitable for MR systems with a magnetic field less than 3.0 T. However, these agents show low contrast efficacy for MR systems with ultrahigh fields >= 7.0 T, which is the direction that next-generation MRI scanners are heading. A new contrast agent consisting of layered gadolinium hydroxide nanoplates doped with Ce and Tb (LGdH:Ce, Tb NPs) is presented herein. This material exhibits excellent negative (T-2) contrast agent efficacy for 7.0 T MRI with a high r(2)/r(1) ratio of 48.80, whereas it exhibits a lower r(2)/r(1) ratio of 30.60 for 3.0 T MRI. Its performance as a T-2 contrast agent in ultrahigh field MRI of subcutaneous liver tumor-bearing nude mice is investigated, demonstrating its ability to be used as a negative target T-2 contrast agent to distinguish hepatic carcinoma from healthy tissues. Furthermore, the multifunctionality of the LGdH:Ce, Tb NPs as a contrast agent in X-ray computed tomography (CT) and fluorescence bioimaging is also presented, suggesting the possibility of integrating these imaging technologies for in-depth exploration of bioimaging. |
| 收录类别 | SCI |
| 原文出处 | http://chinesesites.library.ingentaconnect.com/content/asp/jbn/2014/00000010/00000012/art00011?token=0057189b03dee5ba6720297d76345f7b554a597a407b5e2c6b6d3f6a4b4b6e6e42576b6427387fa517dbec9 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6145]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY |
| 推荐引用方式 GB/T 7714 | Wu, Min,Li, Lei,Yu, Xuefeng,et al. Multifunctional Layered Gadolinium Hydroxide Nanoplates for Ultrahigh Field Magnetic Resonance Imaging, Computed Tomography and Fluorescence Bioimaging[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2014. |
| APA | Wu, Min.,Li, Lei.,Yu, Xuefeng.,Zhang, Daquan.,Sun, Tianying.,...&Zhu, Hongyan.(2014).Multifunctional Layered Gadolinium Hydroxide Nanoplates for Ultrahigh Field Magnetic Resonance Imaging, Computed Tomography and Fluorescence Bioimaging.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY. |
| MLA | Wu, Min,et al."Multifunctional Layered Gadolinium Hydroxide Nanoplates for Ultrahigh Field Magnetic Resonance Imaging, Computed Tomography and Fluorescence Bioimaging".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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