MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells
文献类型：期刊论文
| 作者 | Ma, Zhongliang; Qiu, Xiang; Wang, Detao; Li, Yanli; Zhang, Bingjie; Yuan, Tianwei; Wei, Jiali; Zhao, Botao; Zhao, Xintai; Lou, Jiatao |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2015 |
| 英文摘要 | MicroRNAs play important roles in carcinogenesis and tumor progress. Lung cancer is the leading cause of cancer mortality worldwide. In this study, the function of miR-181a-5p was investigated in non-small-cell lung cancer (NSCLC). Results showed that miR-181a-5pwas significantly decreased inNSCLC tissues and cell lines. The proliferation and migration of A549 cells transfected with miR-181a-5p mimic was significantly inhibited. Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p. Furthermore, Kras was downregulated bymiR-181a-5p at both transcriptional and translational levels. SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic inA549 cells. Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients. |
| 收录类别 | SCI |
| 原文出处 | http://abbs.oxfordjournals.org/content/47/8/630.short |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7329]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA |
| 推荐引用方式 GB/T 7714 | Ma, Zhongliang,Qiu, Xiang,Wang, Detao,et al. MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2015. |
| APA | Ma, Zhongliang.,Qiu, Xiang.,Wang, Detao.,Li, Yanli.,Zhang, Bingjie.,...&Jin, Youxin.(2015).MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA. |
| MLA | Ma, Zhongliang,et al."MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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