Gas Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity
文献类型：期刊论文
| 作者 | Ximing Shao; Ke Liu; Yi Fan; Zhihao Ding; Min Chen; Minyan Zhu; Lee S. Weinstein; Hongchang Li; Huashun Li. |
| 刊名 | Journal of Genetics and Genomics
 |
| 出版日期 | 2015 |
| 英文摘要 | Sphingosine-1-phosphate receptor 1 (S1PR1), a G protein-coupled receptor (GPCR), controls vascular stability by stabilizing vascular endothelial (VE)-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2 (VEGFR2) signaling. However, the molecular mechanisms that link S1PR1 signaling to intracellular effectors remain unknown. In this study, we demonstrate that the heterotrimeric G protein subfamily member Gas, encoded by GNAS, acts as a relay mediator of S1PR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions. The endothelial cell-specific deletion of Gas in mice causes early embryonic lethality with massive hemorrhage and a disorganized vasculature. The immunostaining results revealed that Gas deletion remarkably reduces the junctional localization of VE-cadherin, whereas the mural cell coverage of the vessels is not impaired. In addition, we found that Gas depletion blocks the S1PR1-activation induced VE-cadherin stabilization at junctions, supporting that Gas acts downstream of S1PR1 signaling. Thus, our results demonstrate that Gas is an essential mediator to relay S1PR1 signaling and maintain vascular integrity. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S1673852715001769 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7373]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Journal of Genetics and Genomics |
| 推荐引用方式 GB/T 7714 | Ximing Shao,Ke Liu,Yi Fan,et al. Gas Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity[J]. Journal of Genetics and Genomics,2015. |
| APA | Ximing Shao.,Ke Liu.,Yi Fan.,Zhihao Ding.,Min Chen.,...&Huashun Li..(2015).Gas Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity.Journal of Genetics and Genomics. |
| MLA | Ximing Shao,et al."Gas Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity".Journal of Genetics and Genomics (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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