Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization
文献类型：期刊论文
| 作者 | Ju Gao; Siyue Qin; Chang’an Jiang; |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2015 |
| 英文摘要 | The ubiquitin ligase Parkin and autophagic adapter protein p62 are known to function in a common pathway controlling mitochondrial autophagy (mitophagy). However, the evidence supporting that p62 is directly recruited by ubiquitinated proteins remains undetermined. Here, we demonstrate that mitochondrial fission factor (Mff) associates with Parkin and carbonyl cyanide m-chlorophenyl hydrazone treatment significantly increases the affinity of Parkin with Mff. After recruitment to depolarized mitochondria, Parkin mediates poly-ubiquitination of Mff at lysine 251. Replacement of lysine 251 by arginine (K251R) totally abrogates Parkin-stimulated ubiquitination of Mff. Subsequently, the ubiquitinated Mff promotes its association with p62. Mff knockout interferes with p62 translocation to damaged mitochondria. Only re-transfection of Mff WT, but not K251R mutant, rescues this phenotype. Furthermore, loss of Mff results in failure of Parkin translocation and final clearance of damaged mitochondria. Thus, our data reveal functional links among Mff, p62, and the selective autophagy of mitochondria, which are implicated in the pathogenesis of neurodegeneration diseases. |
| 收录类别 | SCI |
| 原文出处 | http://www.abbs.info/arts.asp?id=3883 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7374]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA |
| 推荐引用方式 GB/T 7714 | Ju Gao,Siyue Qin,Chang’an Jiang；. Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2015. |
| APA | Ju Gao,Siyue Qin,&Chang’an Jiang；.(2015).Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization.ACTA BIOCHIMICA ET BIOPHYSICA SINICA. |
| MLA | Ju Gao,et al."Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization".ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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