Adsorption Force of Fibronectin on Various Surface Chemistries and Its Vital Role in Osteoblast Adhesion
文献类型：期刊论文
| 作者 | Lin Manping; Wang Huaiyu; Ruan Changshun; Xing Juan; Wang Jinfeng; Wang Yuanliang; Luo Yanfeng |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2015 |
| 英文摘要 | The amount, type, and conformation of proteins adsorbed on an implanted biomaterial are believed to influence cell adhesion. Nevertheless, only a few research works have been dedicated to the contribution of protein adsorption force. To verify our hypothesis that the adsorption force of protein on biomaterial is another crucial mediator to cell adhesion, fibronectin (FN) adsorbed on self-assembled monolayers (SAMs) with terminal -OH, -CH3, and -NH2 was quantified for FN adsorption force (Fad) by utilizing a sphere/plane adsorption model and parallel plate flow chamber. As revealed, Fad on SAMs followed a chemistry-dependence of -NH2 > -CH3 >> -OH. It is further demonstrated that Fad together with FN conformation could regulate the late osteoblast adhesion and the consequent reorganization of the adsorbed FN and fibrillogenesis of the endogenous FN. Our study suggests that protein adsorption force plays a key role in cell adhesion and should be involved for better biomaterial design. |
| 收录类别 | SCI |
| 原文出处 | www.ncbi.nlm.nih.gov/pubmed/25685886 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7379]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOMACROMOLECULES |
| 推荐引用方式 GB/T 7714 | Lin Manping,Wang Huaiyu,Ruan Changshun,et al. Adsorption Force of Fibronectin on Various Surface Chemistries and Its Vital Role in Osteoblast Adhesion[J]. BIOMACROMOLECULES,2015. |
| APA | Lin Manping.,Wang Huaiyu.,Ruan Changshun.,Xing Juan.,Wang Jinfeng.,...&Luo Yanfeng.(2015).Adsorption Force of Fibronectin on Various Surface Chemistries and Its Vital Role in Osteoblast Adhesion.BIOMACROMOLECULES. |
| MLA | Lin Manping,et al."Adsorption Force of Fibronectin on Various Surface Chemistries and Its Vital Role in Osteoblast Adhesion".BIOMACROMOLECULES (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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