Surface modification of paclitaxel-loaded tri-block copolymer PLGA-b-PEG-b-PLGA nanoparticles with protamine for liver cancer therapy
文献类型：期刊论文
| 作者 | Nansha Gao; Zhihong Chen; Xiaojun Xiao; Changshun Ruan; Lin Mei; Zhigang Liu; Xiaowei Zeng |
| 刊名 | JOURNAL OF NANOPARTICLE RESEARCH
 |
| 出版日期 | 2015 |
| 英文摘要 | In order to enhance the therapeutic effect of chemotherapy on liver cancer, a biodegradable formulation of protamine-modified paclitaxel-loadedpoly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (PLGA-b-PEG-b-PLGA) nanoparticles (PTX-loaded/protamine NPs) was prepared. Tri-block copolymer PLGA-b-PEG-b-PLGA was synthesized by ring-opening polymerization and characterized by H-1 NMR spectroscopy and gel permeation chromatography. PTX-loaded and PTX-loaded/protamine NPs were characterized in terms of size, size distribution, zeta potential,surface morphology, drug encapsulation efficiency, and drug release. Confocal laser scanning microscopy showed that coumarin 6-loaded/protamineNPs were internalized by hepatocellular carcinoma cell line HepG2. The cellular uptake efficiency of NPs was obviously elevated after protaminemodification. With commercial formulation Taxol(R) as the reference, HepG2 cells were also used to study the cytotoxicity of the NPs. PTX-loaded/protamine NPs exhibited significantly higher cytotoxicity than PTX-loaded NPs and Taxol(R) did. All the results suggested that surfacemodification of PTX-loaded PLGA-b-PEG-b-PLGA NPs with protamine boosted the therapeutic efficacy on liver cancer. |
| 收录类别 | SCI |
| 原文出处 | http://download.springer.com/static/pdf/485/art%253A10.1007%252Fs11051-015-3121-3.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs11051-015-3121-3&token2=exp=1442973149~acl=%2Fstatic%2Fpdf%2F485%2Fart%25253A10.1007%25252Fs11051-015-3121-3.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs11051-015-3121-3*~hmac=35023af6c0e99f81eda8b02a6e2c0eb6cd6e85f370bab4d1e8c2c9a993c15dd6 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7386]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | JOURNAL OF NANOPARTICLE RESEARCH |
| 推荐引用方式 GB/T 7714 | Nansha Gao,Zhihong Chen,Xiaojun Xiao,et al. Surface modification of paclitaxel-loaded tri-block copolymer PLGA-b-PEG-b-PLGA nanoparticles with protamine for liver cancer therapy[J]. JOURNAL OF NANOPARTICLE RESEARCH,2015. |
| APA | Nansha Gao.,Zhihong Chen.,Xiaojun Xiao.,Changshun Ruan.,Lin Mei.,...&Xiaowei Zeng.(2015).Surface modification of paclitaxel-loaded tri-block copolymer PLGA-b-PEG-b-PLGA nanoparticles with protamine for liver cancer therapy.JOURNAL OF NANOPARTICLE RESEARCH. |
| MLA | Nansha Gao,et al."Surface modification of paclitaxel-loaded tri-block copolymer PLGA-b-PEG-b-PLGA nanoparticles with protamine for liver cancer therapy".JOURNAL OF NANOPARTICLE RESEARCH (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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