Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis
文献类型：期刊论文
| 作者 | Y. Chen; T. Wang; M. Guan; W. Zhao; F-K-L. Leung; H. Pan; X. Cao; X.E. Guo; W.W. Lu |
| 刊名 | Osteoarthritis and Cartilage
 |
| 出版日期 | 2015 |
| 英文摘要 | Objective: To investigate changes in bone structure, turnover, and articular cartilage localized in subchondral bone cyst (SBC) regions associated with knee osteoarthritis (OA).Methods: Tibial plateaus (n ¼ 97) were collected from knee OA patients during total knee arthroplasty (TKA). SBCs were identified using micro-computed tomography, and the specimens were divided into non-cyst (n ¼ 25) and bone cyst (n ¼ 72) groups. Microstructure of subchondral bone was assessed using bone volume fraction (BV/TV), trabecular number (Tb.N), structure model index (SMI) and bone mineral density (BMD). In bone cyst group, the cyst subregion, which contained at least one cyst, and the pericyst subregion, which contained no cysts, were further selected for microstructure analysis. Articular cartilage damage was estimated using the Osteoarthritis Research Society International (OARSI) score.The numbers of TRAP þosteoclasts, Osterixþ osteoprogenitors, Osteocalcin þosteoblasts and expression of SOX9 were evaluated by immunohistochemistry. Results: Bone cyst group presented higher BV/TV, Tb.N and SMI at subchondral bone than non-cyst group. Furthermore, cyst subregion displayed increased BV/TV and Tb.N but lower BMD and SMI than peri-cyst subregion. Histology revealed a higher OARSI score in bone cyst group. SBC exhibited a weak relationship with BV/TV, etc. The numbers of TRAP þ osteoclasts, Osterix þ osteoprogenitors, Osteocalcin þ osteoblasts and expression of SOX9, were higher in bone cyst group. Conclusion: SBCs within knee OA are characterized by focally increased bone turnover, altered bone structure and more severe articular cartilage damage. The increased bone turnover possibly contributes to altered bone structure localized in SBC areas, and thus aggravates articular cartilage degeneration. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S1063458415012558 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7388]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Osteoarthritis and Cartilage |
| 推荐引用方式 GB/T 7714 | Y. Chen,T. Wang,M. Guan,et al. Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis[J]. Osteoarthritis and Cartilage,2015. |
| APA | Y. Chen.,T. Wang.,M. Guan.,W. Zhao.,F-K-L. Leung.,...&W.W. Lu.(2015).Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis.Osteoarthritis and Cartilage. |
| MLA | Y. Chen,et al."Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis".Osteoarthritis and Cartilage (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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