Indocyanine Green-Loaded Polydopamine-Reduced Graphene Oxide Nanocomposites with Amplifying Photoacoustic and Photothermal Effects for Cancer Theranostics
文献类型：期刊论文
| 作者 | Hu, Dehong; Zhang, Jingnan; Gao, Guanhui; Sheng, Zonghai; Cui, Haodong; Cai, Lintao |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2016 |
| 英文摘要 | Photoacoustic (PA) imaging and photothermal therapy (PTT) as light-induced theranostic platforms have been attracted much attention in recent years. However, the development of highly efficient and integrated phototheranostic nanoagents for amplifying PA imaging and PTT treatments poses great challenges. Here, we report a novel phototheranostic nanoagent using indocyanine green-loaded polydopamine-reducedgraphene oxide nanocomposites (ICG-PDA-rGO) with amplifying PA and PTT effects for cancertheranostics. The results demonstrate that the PDA layer coating on the surface of rGO could effectively absorb a large number of ICG molecules, quench ICG's fluorescence, and enhance the PDA-rGO's optical absorption at 780 nm. The obtained ICG-PDA-rGO exhibits stronger PTT effect and higher PA contrast than that of pure GO and PDA-rGO. After PA imaging-guided PTT treatments, the tumors in 4T1 breast subcutaneous and orthotopic mice models are suppressed completely and no treatment-induced toxicity being observed. It illustrates that the ICG-PDA-rGO nanocomposites constitute a new class of theranostic nanomedicine for amplifying PA imaging and PTT treatments. |
| 收录类别 | SCI |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876628/ |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10661]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | THERANOSTICS |
| 推荐引用方式 GB/T 7714 | Hu, Dehong,Zhang, Jingnan,Gao, Guanhui,et al. Indocyanine Green-Loaded Polydopamine-Reduced Graphene Oxide Nanocomposites with Amplifying Photoacoustic and Photothermal Effects for Cancer Theranostics[J]. THERANOSTICS,2016. |
| APA | Hu, Dehong,Zhang, Jingnan,Gao, Guanhui,Sheng, Zonghai,Cui, Haodong,&Cai, Lintao.(2016).Indocyanine Green-Loaded Polydopamine-Reduced Graphene Oxide Nanocomposites with Amplifying Photoacoustic and Photothermal Effects for Cancer Theranostics.THERANOSTICS. |
| MLA | Hu, Dehong,et al."Indocyanine Green-Loaded Polydopamine-Reduced Graphene Oxide Nanocomposites with Amplifying Photoacoustic and Photothermal Effects for Cancer Theranostics".THERANOSTICS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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