Multifunctional theranostic nanoparticles for dual-modality imaging and magnetic targeted photodynamic therapy
文献类型：期刊论文
| 作者 | Ding, Zexuan; Liu, Peng; Yi, Huqiang; Wu, Yayun; Zhang, Pengfei; Cai, Lintao |
| 刊名 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
 |
| 出版日期 | 2016 |
| 英文摘要 | Photodynamic therapy (PDT) is an effective treatment for cancer with minimal nonspecific damage to normal tissues. To improve the photodynamic therapeutic efficiency, we loaded superparamagnetic Fe3O4 NPs into the core of redoxresponsive Ce6-conjugated dextran nanoparticles (DSSCe6 NPs), obtaining a multifunctional theranostic system (DSSCe6@Fe3O4 NPs) for dual-modality imaging and magnetic targeted PDT. DSSCe6@Fe3O4 NPs were almost spherical in shape and T2-weighted MR imaging revealed a concentrationdependent darkening effect with the transverse relaxivity coefficient (r2) measured to be 172.3 s−1 mM−1, confirming that it is a good contrast agent in T2-weighted MR images. This theranostic system also exhibits significantly accelerated cellular uptake under magnetic field, and thus offers greatly improved in vitro photodynamic cancer cell killing efficiency. These results indicated that the DSSCe6@Fe3O4 NPs could be a promising theranostic system for cancer imaging and photodynamic therapy. |
| 收录类别 | SCI |
| 原文出处 | https://www.infona.pl/resource/bwmeta1.element.elsevier-089eed15-ebd6-3f43-86e5-bab085d7ca23 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10664]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE |
| 推荐引用方式 GB/T 7714 | Ding, Zexuan,Liu, Peng,Yi, Huqiang,et al. Multifunctional theranostic nanoparticles for dual-modality imaging and magnetic targeted photodynamic therapy[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2016. |
| APA | Ding, Zexuan,Liu, Peng,Yi, Huqiang,Wu, Yayun,Zhang, Pengfei,&Cai, Lintao.(2016).Multifunctional theranostic nanoparticles for dual-modality imaging and magnetic targeted photodynamic therapy.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. |
| MLA | Ding, Zexuan,et al."Multifunctional theranostic nanoparticles for dual-modality imaging and magnetic targeted photodynamic therapy".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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