PLGA-lecithin-PEG-folate core-shell nanoparticles for cisplatin-prodrug targeted delivery
文献类型：期刊论文
| 作者 | Zheng, Mingbin; Gong, Ping; jia, Dongxue; Lu, Yangyang; Zheng, Cuifang; Zhao, Pengfei; Cai, Lintao |
| 刊名 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
 |
| 出版日期 | 2016 |
| 英文摘要 | Cisplatin is one of themostwidely used agents in the treatment of a variety of tumors. However, its toxicity, cross-resistance, and poor targeting limit application of cisplatin. Furthermore its hydrophilic makes it difficult to encapsulate in nanoparticles (NPs) that maintain adequate concentrations for long time periods.1 In this report, we applied a cisplatin-prodrug (c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2 CH2CH2CH3)2]) approach to enhance cisplatin hydrophobicity, using poly(lactic-coglycolic acid) (PLGA-lecithin-polyethylene glycol(PEG)-folate(FA) core–shell NPs as the drug carrier. The cisplatin-prodrug loaded PLGA-lecithin-PEG-FA NPs (FACPNPs) with different cisplatin-prodrug/PLGA weight ratio had the mean size of 109-122 nm, zeta potential of −26 to −33 mV and polydispersity index of 0.1-0.2 very closed to that of original “empty” NPs. Incorporation of prodrug into PLGAlecithin-FA NPs enhanced substantially encapsulation efficiency of cisplatin. FACPNPs had a much higher uptake rate in MCF-7 cells and accumulation in MCF-7 xenograft tumor than free cisplatin. The cell survival rate assays in vitro and chemotherapy in vivo indicated that the FA-CPNPs could efficiently suppressed MCF-7 cells and xenograft tumor. No noticeable abnormality was observed in the heart, liver, spleen, lung and kidneys after the intravenous injection of FA-CPNPs. Our study provided the experiment evidence for the development of novel, effective and safety formulations of platinum drugs. |
| 收录类别 | SCI |
| 原文出处 | http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=9&SID=P1eRI9VnKdtUPE2e36B&page=1&doc=1 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10665]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE |
| 推荐引用方式 GB/T 7714 | Zheng, Mingbin,Gong, Ping,jia, Dongxue,et al. PLGA-lecithin-PEG-folate core-shell nanoparticles for cisplatin-prodrug targeted delivery[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2016. |
| APA | Zheng, Mingbin.,Gong, Ping.,jia, Dongxue.,Lu, Yangyang.,Zheng, Cuifang.,...&Cai, Lintao.(2016).PLGA-lecithin-PEG-folate core-shell nanoparticles for cisplatin-prodrug targeted delivery.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. |
| MLA | Zheng, Mingbin,et al."PLGA-lecithin-PEG-folate core-shell nanoparticles for cisplatin-prodrug targeted delivery".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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