Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy
文献类型：期刊论文
| 作者 | Li, Wenjun; Zheng, Cuifang; Pan, Zhengyin; Chen, Chi; Hu, Dehong; Gao, Guanhui; Cai, Lintao |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2016 |
| 英文摘要 | We here report smart hyaluronidase-actived theranostic nanoparticles based on hyaluronic acid (HA) coupled with chlorin e6 (Ce6) via adipic dihydrazide (ADH) forming HA-ADH-Ce6 conjugates and self assembling into HACE NPs. The resulting nanoparticles showed stable nano-structure in aqueous condition with uniform size distribution and can be actively disassembled in the presence of hyaluronidase (over-expressed in tumor cells), exhibiting hyaluronidase-responsive "OFF/ON" behavior of fluorescence signal. The HACE NPs were rapidly taken up to human lung cancer cells A549 via CD44 (the HA receptor on the surface of tumor cells) receptor mediated endocytosis. Upon laser irradiation, the HACE NPs realized good near-infrared fluorescence imaging and photoacoustic imaging in the tumor bearing mice, which showed 5-fold higher fluorescence intensity and 3-fold higher photoacoustic (PA) intensity than free Ce6, respectively. In addition, under low dose of laser power, the HACE NPs presented more effective photodynamic therapyto suppression of tumor growth than free Ce6 in vitro and in vivo. Overall, these results suggest that the well-defined HACE NPs is a biocompatible theranostic nanoplatform for in vivo dual-modal tumor imaging and phototherapy simultaneously |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0142961216301922 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10680]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOMATERIALS |
| 推荐引用方式 GB/T 7714 | Li, Wenjun,Zheng, Cuifang,Pan, Zhengyin,et al. Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy[J]. BIOMATERIALS,2016. |
| APA | Li, Wenjun.,Zheng, Cuifang.,Pan, Zhengyin.,Chen, Chi.,Hu, Dehong.,...&Cai, Lintao.(2016).Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy.BIOMATERIALS. |
| MLA | Li, Wenjun,et al."Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy".BIOMATERIALS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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