G-Protein alpha-Subunit Gs alpha Is Required for Craniofacial Morphogenesis
文献类型：期刊论文
| 作者 | Lei, Run; Zhang, Ke; Wei, Yanxia; Chen, Min; Weinstein, Lee S.; Hong, Yang; Zhu, Minyan; Li, Hongchang; Li, Huashun |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2016 |
| 英文摘要 | The heterotrimeric G protein subunit Gs alpha couples receptors to activate adenylyl cyclase and is requiredfor the intracellular cAMP response and protein kinase A (PKA) activation. Gs alpha is ubiquitously expressed in many cell types; however, the role of Gs alpha in neural crest cells (NCCs) remains unclear. Here we report that NCCs-specific Gs alpha knockout mice die within hours after birth and exhibit dramaticcraniofacial malformations, including hypoplastic maxilla and mandible, cleft palate and craniofacial skeleton defects. Histological and anatomical analysis reveal that the cleft palate in Gs alpha knockout mice is a secondary defect resulting from craniofacial skeleton deficiencies. In Gs alpha knockout mice, the morphologies of NCCs-derived cranial nerves are normal, but the development of dorsal root and sympathetic ganglia are impaired. Furthermore, loss of Gs alpha in NCCs does not affect cranial NCCs migration or cell proliferation, but significantly accelerate osteochondrogenic differentiation. Taken together, our study suggests that Gs alpha is required for neural crest cells-derived craniofacial development. |
| 收录类别 | SCI |
| 原文出处 | http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=37&SID=X2YrYfmoiTNK5eXSvDg&page=1&doc=1 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10683]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | PLOS ONE |
| 推荐引用方式 GB/T 7714 | Lei, Run,Zhang, Ke,Wei, Yanxia,et al. G-Protein alpha-Subunit Gs alpha Is Required for Craniofacial Morphogenesis[J]. PLOS ONE,2016. |
| APA | Lei, Run.,Zhang, Ke.,Wei, Yanxia.,Chen, Min.,Weinstein, Lee S..,...&Li, Huashun.(2016).G-Protein alpha-Subunit Gs alpha Is Required for Craniofacial Morphogenesis.PLOS ONE. |
| MLA | Lei, Run,et al."G-Protein alpha-Subunit Gs alpha Is Required for Craniofacial Morphogenesis".PLOS ONE (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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