Wnt3a suppresses Wnt/beta-catenin signaling and cancer cell proliferation following serum deprivation
文献类型：期刊论文
| 作者 | He, Qingqing; Yan, Hongwei; Wo, Da; Liu, Junjun; Liu, Peng; Zhang, Jiankang; Li, Limei; Zhou, Bin; Ge, Jin; Li, Huashun |
| 刊名 | EXPERIMENTAL CELL RESEARCH
 |
| 出版日期 | 2016 |
| 英文摘要 | Canonical Wnt/beta-catenin signaling is often aberrantly activated in tumor cells and required for tumor growth. The internalization of Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6) induced by Wnt ligands is commonly thought to be critical for Wnt/beta-catenin signaling activation. However, in contrast to theses previous studies, we here show that persistent excessive stimulation with a canonical Wnt ligand Wnt3a could induce a long-term decreased expression level of membrane LRP6, which prevented nuclear beta-catenin accumulation and tumor cell;proliferation. Importantly, Wnt3a was robustly upregulated following serum deprivation. The upregulated Wnt3a under serum deprivation was responsible for LRP6 internalization, decreased accumulation of nuclear beta-catenin, and further inhibition of tumor cell proliferation. It has well been known that insufficient blood supply during tumor development occurs frequently, causing a worsening environment for tumor growth. Therefore, these results reveal a novel inhibitory role of Wnt3a on canonical Wnt/beta-catenin signaling and cancer cell proliferation when there is an insufficient blood supply during tumor development, which might be a potential mechanism for tumor evasion within a worsening environment. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0014482715301658 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10685]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | EXPERIMENTAL CELL RESEARCH |
| 推荐引用方式 GB/T 7714 | He, Qingqing,Yan, Hongwei,Wo, Da,et al. Wnt3a suppresses Wnt/beta-catenin signaling and cancer cell proliferation following serum deprivation[J]. EXPERIMENTAL CELL RESEARCH,2016. |
| APA | He, Qingqing.,Yan, Hongwei.,Wo, Da.,Liu, Junjun.,Liu, Peng.,...&Zhu, Weidong.(2016).Wnt3a suppresses Wnt/beta-catenin signaling and cancer cell proliferation following serum deprivation.EXPERIMENTAL CELL RESEARCH. |
| MLA | He, Qingqing,et al."Wnt3a suppresses Wnt/beta-catenin signaling and cancer cell proliferation following serum deprivation".EXPERIMENTAL CELL RESEARCH (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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