Magneto-plasmonic nanocapsules for multimodal-imaging and magnetically guided combination cancer therapy
文献类型：期刊论文
| 作者 | Liang Huang; Lijiao Ao; Dehong Hu; Wei Wang; Zonghai Sheng; Wu Su |
| 刊名 | Chemistry of Materials
 |
| 出版日期 | 2016 |
| 英文摘要 | Integrating multiple discrete functionalities into hollow-mesoporous architecture with distinctive electronic/magnetic property is of particular interest for building multifunctional drug carriers with complementary theranostic modalities. In this article, the “non-contact” incorporation of gold nanorod (GNR) into porous magnetic nanoshell is achieved via yolk−shell structure, which was intrinsically different from previous direct chemical or heterogeneous conjugation of the two components. The highly preserved plasmonic feature of GNRs enabled photothermal induced photoacoustic imaging and hyperthermia capabilities. The magnetic shell consisted of stacked primary iron oxide nanocrystals yields strong superparamagnetic response with excellent permeability for magnetically targeted drug delivery. Interestingly, the special coordination between doxorubicin and iron species enabled pH/local heating dual-responsive drug release with minor leakage at neutral pH. Under the guidance of magnetic resonance/photoacoustic dual-modal imaging and magnetically tumor targeting using the nanoagents, the photothermal-chemo synergistic therapy was conducted via near-infrared laser for highly efficient tumor eradication. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.acs.org/doi/pdf/10.1021/acs.chemmater.6b02413 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10690]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Chemistry of Materials |
| 推荐引用方式 GB/T 7714 | Liang Huang,Lijiao Ao,Dehong Hu,et al. Magneto-plasmonic nanocapsules for multimodal-imaging and magnetically guided combination cancer therapy[J]. Chemistry of Materials,2016. |
| APA | Liang Huang,Lijiao Ao,Dehong Hu,Wei Wang,Zonghai Sheng,&Wu Su.(2016).Magneto-plasmonic nanocapsules for multimodal-imaging and magnetically guided combination cancer therapy.Chemistry of Materials. |
| MLA | Liang Huang,et al."Magneto-plasmonic nanocapsules for multimodal-imaging and magnetically guided combination cancer therapy".Chemistry of Materials (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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