Indocyanine green-loaded polydopamine-iron ions coordination nanoparticles for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy.
文献类型：期刊论文
| 作者 | Hu, Dehong; Liu, Chengbo; Song, Liang; Cui, Haodong; Gao, Guanhui; Liu, Peng; Sheng, Zonghai; Cai, Lintao |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2016 |
| 英文摘要 | Multi-modal imaging-guided cancer photothermal therapy (PTT) with advanced theranostic nanoagents can efficiently improve therapeutic efficacy and reduce treatment side effects. Herein, we have developed a theranostic nanoagent based on indocyanine green (ICG)-loaded polydopamine (PDA)-iron ionscoordination nanoparticles (PDA-Fe3+-ICG NPs), which are used for photoacoustic (PA) and magnetic resonance (MR) dual-modal imaging-guided cancerPTT treatments. In this nanoplatform, ICG molecules, the U.S. Food and Drug Administration approved near-infrared (NIR) dye, absorbing on PDA NPs (a melanin-like biopolymer) to significantly increase the NIR optical absorption of PDA NPs nearly 6 times and decreases their fluorescence emission, which can improve the PA contrast ability and promote the photothermal conversion efficiency of PDA NPs. Meanwhile, Fe3+ ions chelated on the PDA NPs act as a T-1-weighted MRI contrast agent (r(1) = 14 mM(-1) s(-1)). In a mouse 4T1 breast tumor model, PA/MRI dual-modal imaging and highly efficient PTT treatments with low laser density were achieved with remarkable therapeutic efficiency and minimal side effects. This study illustrates that the highly integrated and biocompatible PDA-based NPs can serve as a versatile nanoplatform by loading different imaging molecules and drugs for multi-modal imaging and cancercombination therapy. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.rsc.org/-/content/articlehtml/2016/nr/c6nr05502h |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10695]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | NANOSCALE |
| 推荐引用方式 GB/T 7714 | Hu, Dehong,Liu, Chengbo,Song, Liang,et al. Indocyanine green-loaded polydopamine-iron ions coordination nanoparticles for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy.[J]. NANOSCALE,2016. |
| APA | Hu, Dehong.,Liu, Chengbo.,Song, Liang.,Cui, Haodong.,Gao, Guanhui.,...&Cai, Lintao.(2016).Indocyanine green-loaded polydopamine-iron ions coordination nanoparticles for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy..NANOSCALE. |
| MLA | Hu, Dehong,et al."Indocyanine green-loaded polydopamine-iron ions coordination nanoparticles for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy.".NANOSCALE (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。